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Skip to Search Results- 2Li, Leo
- 2Nizio, Katie D
- 1Abdel Latif Ibraheem, Ahmed Abdel Mohsen
- 1Abdelfattah, Ahmed
- 1Abel, Robin Jacob
- 1Abou-Ghanem, Maya
- 33Mass-spectrometry
- 23Organic compounds. Synthesis.
- 21Capillary electrophoresis.
- 21Catalysis
- 21Chemistry
- 20Metabolomics
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Development of Data Processing Methods in Chemical Isotope Labeling Liquid Chromatography-Mass Spectrometry-Based Metabolomics
DownloadSpring 2019
Metabolomics is an active research field on the methods development for the analysis of small metabolites in biological systems. It provides powerful approaches that allow us to examine the variations in the metabolic profiles and is capable of detecting complex biological changes using...
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Derivatization of Amino Acids for Surface Assisted Laser Desorption/Ionization (SALDI) Mass Spectrometry Analysis
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Metabolites with low molar mass, such as amino acids, are of great importance in disease diagnosis. The rapid and accurate detection of amino acids and other small metabolites in biological samples has become significantly important. Surface assisted laser desorption/ionization (SALDI) has been...
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The Catalytic Role of a Single Water on Keto-Enol Tautomerization Explored by Fourier Transform Microwave Spectroscopy and Ab Initio Calculations
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Keto-enol tautomerization plays important roles in biochemistry, atmospheric chemistry, and crystallography. It has attracted much attention for a long time. Solvation (hydration) is found to play essential roles in controlling this tautomerization process. Here, the effects of a single water...
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Fall 2019
This thesis focuses on the development and application of electrospray ionization mass spectrometry (ESI-MS) based methods for characterizing glycoproteins (GPs) and investigating their interactions with glycan binding proteins (GBPs) and drugs. A multipronged approach was developed to identify...
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Studies Undertaken Towards the Total Synthesis of Antifreeze Compounds Based on the Xylomannan Antifreeze from the Alaskan Beetle Upis ceramboides
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Biological antifreeze substances are widely found in the tissues of cold-blooded organisms indigenous to polar environments. Prior to 2009, all these compounds were associated with protein, leading to the widespread assumption that all biological antifreeze substances must possess a protein or...
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Spring 2020
Polycyclic aromatic hydrocarbons (PAHs), or more specifically pentacene derivatives, are promising candidates for solar energy conversion. Pentacenes can undergo π-stacking in solution and, consequently, can be poorly soluble. Furthermore, the pentacene moiety can react with oxygen, and it can...
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Synthesis, Structure and Properties of a Novel “Frustrated” Benzoxaborole and the Role of Boron in Bioconjugation
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Chapter 2 describes an optimized 7-step successful synthesis of a first of its kind permanently open-form ortho-hydroxyalkyl arylboronic acid, otherwise known as a “frustrated benzoxaborole”, with a columnless purification and complete structure elucidation. This novel compound is completely...
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Development of Rhodium Catalyzed Formic Acid Mediated Z-Selective Alkene Synthesis from Electron Deficient Dienes
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Z-Alkenes are important functional moieties in biological molecules and serve as versatile units for chemical transformations in synthetic chemistry. Synthetic strategies to readily generate these less thermodynamically stable alkenes with high regio-, chemo- and stereocontrol remain challenging,...
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Computational Study of the Rare Gas Fluorohydrides, Cyanohydrides, and Isocyanohydrides: Structures, Reactions, and Electronic Spectra
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Little work on the electronic excited states of the family of HRgY (where Rg = rare gas and Y = electronegative group) compounds exist. There are two problems that are studied. The first is work aimed at extending the HRgY excited state area of research to include more work done on the electronic...
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Fall 2020
Pereira Carvalho, Wildemar Stefanio
We have witnessed significant progress in the past few decades in the development of stimuli-responsive polymer-based smart materials. A great deal of work has been dedicated to the development of sensors and biosensors that are portable, inexpensive and easy-to-use to be used in resource limited...