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- 2Graduate Studies and Research, Faculty of
- 2Graduate Studies and Research, Faculty of/Theses and Dissertations
- 2Medicine and Dentistry, Faculty of
- 2Medicine and Dentistry, Faculty of/Alberta Research Centre for Health Evidence (ARCHE)
- 1Pediatrics, Department of
- 1Pediatrics, Department of/Complementary and Alternative Research and Education (CARE)
The increasing popularity of traditional Chinese medicine (TCM) therapies as health care options warrants thorough examination of the efficacy and safety evidence around these therapies. This thesis explores the intersection of TCM and fatigue using two rigorous methodologies: systematic reviews...
Applying the risk of bias tool in a systematic review of combination long-acting beta-agonists and inhaled corticosteroids for persistent asthma.Download
Background The Risk of Bias (RoB) tool is used to assess internal validity of randomized controlled trials (RCTs). Our objectives were to: 1) evaluate inter-rater agreement of the RoB tool; 2) determine the time to access supplemental study information; 3) compare the RoB tool with the Jadad...
Objective: To quantify bias related to specific methodological characteristics in child-relevant randomized controlled trials (RCTs). Design: Meta-epidemiological study. Data Sources: We identified systematic reviews containing a meta-analysis with 10–40 RCTs that were relevant to child health in...
Primary Outcomes Reporting in Trials (PORTal): a systematic review of inadequate reporting in pediatric randomized controlled trialsDownload
Objective: Conduct a systematic review of pediatric randomized controlled trials published in high impact journals to assess the reporting of primary outcomes and the psychometric properties of their measures. Study Design and Setting: Systematic review with screening and simultaneous data...
Background: There is emerging evidence that randomized trials are subject to biases. Flaws in the design of such trials can result in over- or underestimation of the treatment effect size. Aim: To examine the empirical evidence for bias, to quantify the extent of bias associated with methodology,...