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Skip to Search Results- 6Department of Chemistry
- 4Department of Electrical and Computer Engineering
- 3Department of Agricultural, Food, and Nutritional Science
- 2Department of Medicine
- 1Department of Agricultural, Food and Nutritional Science
- 1Department of Biochemistry
- 2Kurgan, Lukasz (Electrical and Computer Engineering)
- 1Ball, Ronald O. (Department of Agricultural, Food and Nutritional Science)
- 1Ballermann, Barbara (Medicine)
- 1Boekhoven, Job (Chemistry, Technical University of Munich)
- 1D. Jed Harrison (Chemistry)
- 1Dr. Barbara Ballermann (Department of Medicine, University of Alberta)
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Fall 2011
Proteins, which participate in virtually every process within cells, implement many of their functions through interactions with various ligands. Although a substantial effort in characterization and prediction of protein-ligand interactions was observed in the past two decades, these subjects...
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Interfacing Silicon-Based Quantum Dots with Proteins for Biological and Sensing Applications
DownloadFall 2020
This dissertation presents the preparation of functional bioinorganic hybrids from silicon-based quantum dots (SiQDs) and enzymes and the use of SiQDs and green fluorescent protein as ratiometric photoluminescent sensors for nerve agents. Chapter 2 discusses the preparation of water-soluble...
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Fall 2024
The chloride intracellular channel (CLIC) isoform 5A was discovered in a complex with ezrin and actin in placenta microvilli. CLIC5A is also greatly enriched in kidney glomeruli and is essential for assembly of the ezrin/NHERF2/podocalyxin complex at the apical domain of glomerular podocyte foot...
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Simultaneous measurement of protein and energy metabolism and application to determine lysine requirements in sows
DownloadSpring 2011
Simultaneous measurements of energy and protein metabolism can provide valuable information about their interactions. Dietary lysine is limiting in typical feedstuffs fed to swine and, therefore, limits protein synthesis. Current recommendations for dietary amino acid and energy intakes may not...
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Structure and dynamics of biomolecules: probing muscle regulation, prion protein unfolding, and drug insertion into DNA by nuclear magnetic resonance spectroscopy
DownloadSpring 2011
Nuclear magnetic resonance (NMR) spectroscopy is a powerful approach to study the structure and dynamics of macromolecules in a close-to-native solution environment. In the present thesis I present my investigation of protein and nucleic acid structure and dynamics in a wide variety of biological...
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Synthesis, biological evaluation, and screening of 2,5-anhydro-D-mannitol derivatives towards selective targeting and imaging of GLUT5 transporter protein
DownloadFall 2022
The solute carrier (SLC) family of membrane proteins is responsible for the internalization of a variety of essential small molecule compounds such as amino acids, monosaccharides, neurotransmitters, vitamins, as well as many inorganic ions. In recent years, these proteins have been recognized as...
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Fall 2018
Chloride intracellular channel (CLIC) proteins comprise six members CLIC1–CLIC6 in mammals and mediate functions not fully known. Their founding member was isolated from bovine kidney using the chloride channel inhibitor indanyloxyacetic acid-94, so CLICs were assumed to be typical anion...