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Skip to Search Results- 1Alpaugh, Melanie J
- 1Beveridge, Michelle H
- 1Chen, Christopher B
- 1Duffy, Terri-Lynn
- 1Kang, Dong-Woo
- 1Khodayari Moez, Elham
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Impact of conventional fractionated RT to pelvic lymph nodes and dose-escalated hypofractionated RT to prostate gland using IMRT treatment delivery in high-risk prostate cancer
DownloadFall 2009
Prostate cancer is the most common cancer among Canadian men. The standard treatment in high-risk category is radical radiation, with androgen suppression treatment (AST). Significant disease progression is reported despite this approach. Radiation dose escalation has been shown to improve...
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Ganglioside Increases Metastatic Potential and Susceptibility of Prostate Cancer to Gene Therapy in vitro
DownloadFall 2009
Prostate cancer (CaP) is the 2nd most common cancer in North American men. Tumour management strategies are appropriate for early stage disease, but advanced disease has a poor prognosis and requires prompt treatment. Therefore, research into delay of tumour progression and efficacious treatment...
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Giardiasis in children attending daycare centers in Guatemala and the therapeutic potential of ganglioside
DownloadSpring 2011
Intestinal enteropathy is a prevalent yet neglected aspect of child malnutrition involving chronic exposure to intestinal pathogens such as Giardia intestinalis. Gangliosides have therapeutic potential for the treatment of giardiasis and intestinal enteropathy. The objectives of the thesis were...
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Fall 2013
Inflammatory bowel disease (IBD) involves chronic inflammation of all or part of the digestive tract. IBD primarily includes ulcerative colitis and Crohn disease. Gangliosides are negatively charged glycosphingolipids that consist of a hydrophobic ceramide and a hydrophilic oligosaccharide chain...
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Altered ganglioside metabolism in inflammatory bowel disease and the impact of dietary ganglioside intake
DownloadFall 2014
Gangliosides are integral to the structure and function of the plasma membrane. Ganglioside composition of the small intestinal brush border membrane and apical surface of the colon influence numerous cell processes including microbial attachment, cell division, differentiation, and signaling....
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Gangliosides in Plasma and Chylomicrons of Control Participants and Individuals with Diabetes Fed both a High- and Low-Fat Diet
DownloadFall 2014
Aim: To investigate whether the plasma and chylomicron ganglioside profiles of participants with type 2 diabetes differ from those of matched control participants at 0, 2, 4, 6 and 8 hours postprandial when individuals are fed both a high- and low-fat diet for three days each. Background: Type 2...
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Spring 2015
This research determined if alteration of plasma membrane by exogenous gangliosides inhibits Helicobacter pylori adhesion to human gastric epithelial cells. The objective was to evaluate the composition of gangliosides from bovine whole raw milk, bovine colostrum and powder buttermilk using...
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Therapeutic effects of ganlgioside GM1 and gangliomimetic compounds in multiple models of Huntington disease
DownloadSpring 2016
Huntington disease (HD) is a neurodegenerative disorder that results in motor, cognitive and psychiatric deficits. The disease is caused by the expansion of a polyglutamine stretch in huntingtin (HTT), a ubiquitous protein with unclear functions. The molecular mechanisms underlying...
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Fall 2016
Relative to those without diabetes, individuals with type 2 diabetes have an increased risk of several cancers, but a decreased risk of prostate cancer. While metformin may reduce the risk of some cancers, it may not reduce the risk of prostate cancer. However, race/ethnicity may modify...
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Fall 2018
Human genomic data are being generated at an increasing rate owing to the advancement of high-throughput technology. Wider availability of genomics, transcriptomics, proteomics and metabolomics data motivated complex study questions with the intention to gain higher degree of understanding of...