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Skip to Search Results- 4Positron emission tomography
- 2Tyrosine kinase inhibitor
- 13′-deoxy-3′-fluorothymidine
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Characterization of transport of positron emission tomography tracer 3′-deoxy-3′-fluorothymidine by nucleoside transporters
DownloadFall 2012
Positron emission tomography (PET) tracer 3′-fluoro-3′-deoxythymidine (FLT) is used for imaging tumor proliferation. Prior to this work, human equilibrative nucleoside transporter 1 (hENT1) was the only known human nucleoside transporter (hNT) capable of FLT transport. The aim of this research...
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Structure-Affinity Relationship Study of Novel Imidazoline Ligands at Imidazoline Binding Sites and α-Adrenoceptors
DownloadFall 2014
Many drugs containing an imidazoline moiety are thought to bind to both imidazoline binding sites (IBS) and α-adrenoceptors (α-AR) to mediate their therapeutic effects. To aid in better characterisation of these binding sites, the structure-affinity relationships of several new series of...
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Utilizing Positron Emission Tomography to Detect Functional Changes Following Drug Therapy in a Renal Cell Carcinoma Mouse Model
DownloadSpring 2013
Sunitinib is currently the first line drug therapy for metastasizing renal cell carcinoma (RCC). It has been shown to have a profound effect on tumor angiogenesis leading to modifications of the tumor’s microenvironment. Tumor hypoxia plays an important role in the metastatic potential of a solid...