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- 1Abbasi Dezfouli, Meysam
- 1Akin, Oguz
- 1Amin, Muhammad Ruhul
- 1Bayati, Fatemeh
- 1Bhambri, Pallavi
- 1Bhuchar, Neha
- 9Department of Chemical and Materials Engineering
- 4Department of Mechanical Engineering
- 2Department of Biomedical Engineering
- 2Department of Chemistry
- 2Department of Electrical and Computer Engineering
- 1Department of Agricultural, Food and Nutritional Science
- 2Choi, Phillip (Chemical and Materials Engineering)
- 1Backhouse, Chris (Electrical and Computer Engineering, University of Waterloo)
- 1Boluk, Yaman (Civil and Environmental Engineering)
- 1Buriak, Jillian M. (Chemistry)
- 1Davies, Evan (Civil and Environmental Engineering)
- 1Davis, John (Physics)
Delivery of STAT3 inhibitor cucurbitacins to tumor by polymeric nano-carriers : Implications in cancer chemo- and immunotherapyDownload
Signal Transducer and Activator of Transcription 3 (STAT3), a common oncogenic mediator, is constitutively activated in many types of human cancers and plays a critical role in tumor growth and cancer immune evasion. The focus of this dissertation is the delivery of STAT3 inhibitor cucurbitacins...
Lipid Modified Polymers for Transfection of Human CRL Fibroblasts, and for siRNA Mediated MDR Reversal in Melanoma Cancer TherapyDownload
Gene delivery for therapeutic purposes is quickly emerging as the best potential treatment option for inherited genetic diseases and cancer. Viral gene carriers have been the choice for this purpose due to their high efficiency, but harmful immunogenic and oncogenic host reactions have limited...
Synthesis and Characterization of Phosphorylcholine-based Polymers and Nanogels via the Reversible Addition Fragmentation Chain Transfer ProcessDownload
2-Methacryloyloxyethyl Phosphorylcholine is an interesting biocompatible monomer. An improved method for the synthesis of poly(MPC) and its copolymers using Reversible Addition-Fragmentation chain Transfer (RAFT) has been discussed in the first part of the thesis. Previous reports related to the...
Coupling supercritical CO2 extraction with membrane separation leads to energy savings by recycling CO2 at supercritical state while separating extract components. Commercially available polyamide-based membranes are commonly used with coupled systems due to their availability and robust...
The following thesis describes original studies assessing the gene delivery efficacy of novel non-viral carrier combinations. The first panel of non-viral carriers tested are termed AVPs (artificial viral particles), in reference to their structural similarity to enveloped viruses, and were...
An alternative method of manipulating fragile MEMS devices during fabrication has been developed. A specialized manual or robotic end effector utilizing a gecko inspired adhesive can replace the slow and costly manual tweezers used by the MEMS foundry Micralyne Inc. Improving the adhesive...
This thesis investigates electrically conductive polymer nanocomposites formulated with metal nanowires for electrostatic discharge and electromagnetic interference shielding. Copper nanowires (CuNWs) of an average length of 1.98 µm and diameter of 25 ± 4 nm were synthesized. The oxidation...
Management of oil sands tailings from bitumen extraction operations remains a challenge for mineable oil sands producers. Promoting fine solids settling in tailings ponds is key to treating oil sands tailings. Present study explores two methods of tailings treatment – ATA process and polymer...
Storm water ponds have been widely constructed over the past four decades as part of municipal storm water drainage systems. These ponds are designed to collect neighborhood storm water run-off to reduce flooding, but can also improve the quality of water discharged to surface water bodies by...