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- 1Froentjes, Liesbeth
- 1Goplen, Craig M
- 1Kantor, Chase M
- 1Kerridge, Teresa A.
- 1Kokate, Tushar G.
- 1Panaitescu, Bogdan Alexandru
Modulation of Spontaneous Neural Network Bursting in Newborn Rat Brain Slices by Extracellular Calcium, Methylxanthines, and OpioidsDownload
Spontaneous neuronal bursting appears to be pivotal for brain maturation. This thesis studied such synchronized neural network oscillations in immature newborn rat hippocampus, cortex, and locus coeruleus. For this, horizontal brain slices were generated for (simultaneous) suction electrode...
Antagonistic modulation of spontaneous neural network activities in isolated newborn rat brainstem preparations by opioids and methylxanthinesDownload
Apnea of prematurity is a common problem among the infants born before term pregnancy. Administration of respiratory stimulating drugs methylxanthines is the most frequent therapy, often in combination with the use of intubation. Opioids are used to reduce the pain associated with intubation,...
Efficacy and side-effect profiles of lactulose, docusate sodium, and sennosides compared to PEG in opioid-induced constipation: A systematic reviewDownload
Opioid-induced constipation (OIC) is an unpleasant and ubiquitous side effect of opioid treatment. Ineffective treatment of OIC can result in decreased adherence to opioid therapy, decreased quality of life, and increased morbidity and mortality. The constipating effects of opioids result from...
Background: Up to 40% of patients are prescribed opioids prior to total knee arthroplasty (TKA) in the USA. These patients prescribed preoperative opioids have increased complications and worse outcomes after surgery. But, the impact of preoperative opioid use on patient-reported outcome (PRO)...
Short, Intermediate, and Long-Term Effects of Opioids on Pain Intensity in Patients with Osteoarthritis or Low Back Pain: A Systematic Review and Meta-AnalysisDownload
Chronic opioid use is associated with the development of hyperalgesia, which may end up attenuating any analgesic benefits over long-term therapy. We wanted to determine whether the analgesic efficacy of opioids compared to control therapy for osteoarthritis and chronic lower back pain differed...