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Skip to Search Results- 8Next-generation sequencing
- 7Skeletal muscles
- 4MicroRNAs
- 3Cachexia
- 2Gene-expression
- 2Myosin heavy chain
- 1Almasud, Alaa A
- 1Esfandiari, Nina
- 1Galindo González, Leonardo M
- 1Hasing Rodriguez, Maria E
- 1Khorshidi, Azam
- 1Krishnan, Preethi
- 3Department of Agricultural, Food, and Nutritional Science
- 3Department of Biological Sciences
- 3Medical Sciences-Laboratory Medicine and Pathology
- 2Department of Oncology
- 1Department of Medicine
- 1Faculty of Physical Education and Recreation
- 2Baracos, Vickie (Oncology)
- 2Damaraju, Sambasivarao (Laboratory Medicine and Pathology)
- 2Putman, Charles (Physical Education and Recreation)
- 1Ali, Declan W. (Biological Sciences)
- 1Baracos, Vickie (Oncology & Agricultural, Food, and Nutritional Science)
- 1Boucher, Yan (Biological Sciences)
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Application of Next Generation Sequencing and Bioinformatic Approaches to the Study of Influenza Virus Strains and MiRNA Profiling in Liver Diseases
DownloadSpring 2016
Analysis and interpretation of next generation sequencing data has posed a significant challenge to researchers, especially to those who are not equipped with expertise in bioinformatics. In this thesis, I investigated three different biomedical questions using NGS and bioinformatic approaches,...
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Characterization of Norovirus strains and a seroprevalence study to understand the fluctuation of outbreak activity in Alberta, Canada
DownloadFall 2016
Norovirus (NoV) is recognized as the leading agent causing gastroenteritis among individuals of all ages. Historical data of NoV outbreak surveillance in Alberta, Canada, from the period July 2000 to June 2008 demonstrated a biennial pattern of NoV outbreak activity, in which peaks of high...
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Combined Assembly of Metagenomic Libraries from The Faecal Samples of IBD and PSC Patients Allowed The Identification of African Swine Fever Virus-like Sequences
DownloadSpring 2015
Metagenomics is an emerging discipline to explore microbial diversity in clinical samples, independent of the limitations of cell cultures. This method is widely accepted as a modern technique to detect novel viruses in clinical and environmental samples and has the potential to contribute to the...
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Elevated Fatty Acid Content in Muscle is Prevented by EPA and DHA in an Animal Model of Colorectal Cancer Receiving CPT-11 / 5-FU
DownloadFall 2012
This study aimed to assess the effect of irinotecan / 5-fluorouracil treatment on amount and types of fatty acids in skeletal muscles of tumor-bearing rats fed: a) control diet, b) fish oil diet. Rats bearing the Ward colorectal carcinoma were fed a semi-purified diet with or without fish oil...
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Fibre-Type Specific Nuclear Localisation Patterns of NFAT-isoforms in CLFS Induced Skeletal Muscle Adaptations
DownloadSpring 2014
The purpose of this investigation was to characterize the nuclear localisation patterns of NFAT-c1, -c2, -c3, and -c4 in relation to chronic low-frequency stimulation induced fibre type transitions. A model has been suggested to describe the roles of all 4 NFAT isoforms in activity-dependent...
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Profiling and Identification of Post-Transcriptional Regulatory Molecules for Human Cancer Cachexia
DownloadSpring 2017
Cancer cachexia (CC) is a multifactorial syndrome characterized by severe depletion of skeletal muscle, with or without fat loss. A majority of cancer patients with incurable cancer are affected with cachexia and it remains an unmet medical need. Gene expression changes at the transcriptional...
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Profiling and Identification of Small Non-coding RNAs as Prognostic Markers for Breast Cancer
DownloadFall 2016
Breast cancer (BC) continues to be one of the leading causes of cancer related death among women. Despite continuous progress in screening, diagnosis and treatment of BC, a subset of patients experience recurrence and/or death. Optimal management of BC has remained a challenge due to these...
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Spring 2018
MicroRNAs (miRNAs) are small non-coding RNAs, which are known to regulate plant responses to abiotic stresses, such as Cold Stress (CS) and during normal growth and development. In Brassica napus (canola), miRNAs regulate various developmental processes and responses to metal stress however;...
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STRESS RESPONSES OF THE FLAX GENOME: ACTIVATION OF TRANSPOSABLE ELEMENTS, DEFENSE GENES AND GENOME RESTRUCTURING AND DIVERSIFICATION.
DownloadSpring 2017
Transposable elements (TEs) are DNA sequences that can move in the genome (transpose) via a DNA or a RNA intermediate. TEs are abundant in plant genomes and can be activated by stress. Their activity can result in structural and gene expression alterations that increase diversity within and among...
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Fall 2009
Skeletal muscle is a heterogeneous, multinucleated, post-mitotic tissue that contains many functionally diverse fibre types that are capable of adjusting their phenotypic properties in response to altered contractile demands. This plasticity, or adaptability of skeletal muscle is largely...