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Skip to Search Results- 1Adams, Scott C
- 1Alabi, Adekunle
- 1Aldana Hernandez, Paulina
- 1Azad, Abul K
- 1Darvesh, Nazia
- 1Haave Audet, Elene
- 3Department of Agricultural, Food, and Nutritional Science
- 2Department of Biological Sciences
- 2Physical Education and Recreation
- 1Department of Agricultural, Food and Nutritional Science
- 1Department of Biochemistry
- 1Department of Medicine
- 2Proctor, Spencer (Agricultural, Food and Nutritional Science)
- 1Baksh, Shairaz (Pedritics)
- 1Boutin, Stan (Biological Sciences)
- 1Carson, Valerie (Physical Education and Recreation); Spence, John C. (Physical Education and Recreation)
- 1Courneya, Kerry (Physical Education and Recreation)
- 1Davidge, Sandra T (Ob/Gyn, Physiology)
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The role of ezetimibe and simvastatin in modulating intestinal cholesterol transport, chylomicron profile and chylomicron-remnant uptake by the arterial wall in a rodent model of the metabolic syndrome
DownloadFall 2010
Intestinally derived chylomicron remnants (CM-r) may contribute to atherogenic dyslipidemia during the Metabolic Syndrome (Mets). However, the combined effects of ezetimibe (EZ) and simvastatin (SV) on post-prandial (PP) dyslipidemia during MetS remains unclear, nor is it known whether the...
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The Role of Intestinal Derived Remnant Lipoproteins in the Progression of Atherosclerosis in Animal Models of Type 1 and Type 2 Diabetes.
DownloadFall 2011
Introduction: Subjects with insulin resistance (IR) and diabetes are at increased risk of cardiovascular disease (CVD) than those without diabetes, however the mechanistic basis remains elusive. Despite LDL-cholesterol lowering by statin therapy, two-thirds of all CVD events remain, constituting...
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Spring 2014
Lower-extremity peripheral artery disease (PAD) is a manifestation of atherosclerotic disease in the lower limbs. PAD is a risk factor for poor outcomes including myocardial infarction, stroke, and mortality. Despite the potential benefits of early PAD detection, in the majority of PAD cases...
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Spring 2014
Modifiable cardiovascular disease (CVD) risk factors, such as adiposity, are already associated with atherosclerotic progression in childhood. Less is known about whether physical activity (PA) is associated with progression of atherosclerosis in non-clinical samples of children. This...
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Investigating the role of coiled-coil domain containing protein 3 (CCDC3), a novel secreted protein, in endothelial inflammation
DownloadFall 2015
Endothelial inflammation is critical in the initiation and progression of atherosclerosis and other cardiovascular diseases (CVDs). Tumor necrosis factor-α (TNF-α) is a pro-inflammatory cytokine that induces endothelial inflammation via activation of nuclear factor κB (NF-κB) signaling....
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Longitudinal and cross-sectional associations between physical activity, screen time, and fitness in a sample of young children from Edmonton, Canada
DownloadFall 2016
Background: High fitness is associated with several positive health outcomes; however, fitness of Canadian children has declined over the past two decades. Correlates of fitness in children under 10 years of age are relatively unexplored, and few studies involving young children have looked at...
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Fall 2017
Phosphatidylethanolamine N-methyltransferase (PEMT) is a hepatic enzyme that converts phosphatidylethanolamine to phosphatidylcholine. Pemt-/- mice are protected from obesity and insulin resistance, a phenotype that is reversed with dietary choline supplementation. Additionally, PEMT deficiency...
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Effects of High-Intensity Aerobic Interval Training on Cardiovascular Disease Risk and Health-related Quality of Life in Testicular Cancer Survivors: The HIITTS Trial
DownloadFall 2017
Background: Testicular cancer (TC) survivors (TCS) are an understudied, high-risk group susceptible to late-onset treatment-related cardiovascular disease (CVD), psychosocial, and health-related quality of life (HRQoL) deficits in the years following treatment. Importantly, despite having the...
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Resources and Reproductive Trade-offs Affect Fitness, Life History Traits, and Sexual Selection in Red Squirrels
DownloadSpring 2017
Animals face trade-offs throughout life between competing functions, such as between self-maintenance, reproduction, and survival. Resource allocation between these competing functions leads to different patterns of life history traits, changes in investment in reproductive effort, and different...
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Insights into Membrane Type-1 Matrix Metalloproteinase cleavage of the Low-density Lipoprotein Receptor
DownloadSpring 2021
The Low-density lipoprotein receptor (LDLR) mediated cellular uptake of LDL is the main pathway for plasma LDL cholesterol (LDL-C) clearance. However, the LDLR can be proteolytically cleaved to release its soluble ectodomain (sLDLR) into the extracellular milieu and as such reducing its LDL-C...