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Axial patterning of the developing vertebrate eye is crucial for proper axon pathfinding, as well as critically important morphogenetic events such as closure of the ocular fissure. Perturbations in eye morphogenesis can lead to ocular coloboma (failed ocular fissure closure) and microphthalmia...
DHR51 as a coordinator of heme biosynthesis and steroid hormone production to time metamorphosis in Drosophila melanogasterDownload
Development from a juvenile to an adult animal is driven by pulses of steroid hormones released at precise developmental times. Inputs from the environment, timing cues, and nutritional factors are all coordinated to produce a steroid hormone pulse. Insects and in particular, the fruit fly...