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Skip to Search Results- 1Banadyga, Logan Elliott
- 1Burles, Kristin A
- 1Campbell, Stephanie D
- 1Chaurasiya, Shyambabu
- 1Crosley, Powel
- 1Gammon, Donald Brad
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Fall 2010
Herpes Simplex Virus Type 1 (HSV-1) establishes latent infections in neurons in vivo and lytic infections in epithelial cells and fibroblasts. During latent infections, HSV-1 transcription is restricted and the genomes are not replicated. Latent HSV-1 genomes are chromatinized, such that...
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Anti-Cancer Mechanism of Trastuzumab via Blocking Nuclear HER2 Function and Epigenetic Mechanism of Resistance
DownloadSpring 2020
HER2 receptor tyrosine kinase (encoded by ERBB2 gene) is overexpressed in approximately 25% of all breast cancer tumors (known as HER2-positive breast cancers). Overexpression of HER2 causes overactivation of downstream receptor tyrosine kinase pathways including PI3K/Akt and MAPK pathways and is...
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Fall 2012
One of the most notable features of poxviruses is their ability to regulate cellular signaling pathways, including the ubiquitin-proteasome system. Ubiquitin plays a crucial role in the fate of a protein. Typically poly-ubiquitinated proteins are degraded by the 26S proteasome. The Skp1,...
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Fall 2015
Many cellular processes are regulated by the ubiquitin proteasome system (UPS), which utilizes the polypeptide ubiquitin to mark proteins for destruction via the 26S proteasome. Since the UPS plays an important role in cellular homeostasis, many viruses have evolved strategies to regulate the...
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Spring 2022
Primary herpes simplex virus 1 (HSV-1) infections are common in childhood, affecting mainly the oropharyngeal mucosa. The virus is then transported to the neuronal bodies in the trigeminal ganglia, where it establishes lifelong latency. Although latent infections are asymptomatic, HSV-1...
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Fall 2010
Asf1 is a conserved H3/H4 histone chaperone with multiple functions in chromatin modulation. Using budding yeast as a model, we identify new pathways of Asf1 function, and expand current knowledge regarding the known roles of Asf1. First, we uncover novel genetic interactions between ASF1 and...
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Deletion of F4L (ribonucleotide reductase) in Vaccinia Virus Produces a Selective Oncolytic Virus and Promotes Anti-tumor Immunity with Superior Safety in Bladder Cancer
DownloadFall 2017
Overall recurrence of non-muscle-invasive bladder cancer (NMIBC) can be as high as 80% within 5 years of initial treatment. High-grade NMIBC has the greatest risk of recurrence and treatment for these patients includes surgery followed by intravesical therapy with the immunotherapeutic agent...
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Spring 2013
Chromatin plays a pivotal role in regulating critical DNA dependent processes, such as transcription. Chromatin and associated epigenetic modifications form the molecular basis of differentiation and development and are misregulated in disease states, such as cancer. Histone H1 molecules are key...
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Ectromelia Virus Encodes A Novel Family Of Ankyrin/F-box Proteins That Manipulate The SCF Ubiquitin Ligase And NF-κB Activation
DownloadSpring 2012
Ectromelia virus (ECTV) is the causative agent of lethal mousepox, and is highly related to the human pathogen, variola virus, the causative agent of smallpox. Poxviruses contain large dsDNA genomes that encode numerous open reading frames that manipulate cellular signalling pathways. We used...
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How studying the interaction of Sir4 with a subset of Nups uncovered a new chromatin bound complex.
DownloadFall 2017
The nucleus is the defining feature of eukaryotic cells and its major function is to house the cell’s genome and segregate it from the surrounding cytoplasm. The membranes encapsulating the nucleus constitute the nuclear envelope (NE). The interactions between the NE and chromatin facilitate the...