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Skip to Search Results- 2Veldhoen, Richard
- 1Abdualmjid,Reem J
- 1Abdurrahim, Amna E.
- 1Araya, Luam Ellen
- 1Baghdasarian, Argishti
- 1Banadyga, Logan Elliott
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Retrograde signaling mechanisms of nerve growth factor regulating the survival and apoptosis of sympathetic neurons
DownloadFall 2009
The survival of several neuron populations during development, including sympathetic neurons, is strictly regulated by neurotrophins such as nerve growth factor (NGF) released from innervation targets. NGF activates its receptor, TrkA, at axon terminals, to generate signals that are transmitted...
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Characterization of the response of melanoma cell lines to inhibition of anti-apoptotic Bcl-2 proteins
DownloadSpring 2010
Malignant melanoma is resistant to almost all conventional forms of chemotherapy. Recent evidence suggests that anti-apoptotic proteins of the Bcl-2 family are overexpressed in melanoma and may contribute to melanoma’s striking resistance to apoptosis. ABT-737, a small-molecule inhibitor of...
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Spring 2010
Heterogeneity of surfaces is often included in mathematical treatments of colloid transport and deposition as an afterthought, if at all. Most previous models of colloid transport and deposition have employed idealizations and simplifications such as assuming smooth collector surfaces with...
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An examination of parent-child dyadic interaction and the impact of a parent-training program designed to support the language development of toddlers diagnosed with autism spectrum disorder (ASD)
DownloadFall 2010
Parents can effectively facilitate positive child behaviour change (Kaiser & Hancock, 2003). Their inclusion as interventionists is an essential component of autism intervention (NRC, 2001) and represents a natural step toward consistent early intervention. However, what constitutes effective...
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Insights into the role of CTP:phosphocholine cytidylyltransferase-alpha in hepatic lipid metabolism and cellular integrity
DownloadFall 2011
Lower levels of hepatic phosphatidylcholine (PC) are suggested to play a role in the pathogenesis of non-alcoholic steatohepatitis (NASH). Mice lacking hepatic CTP:phosphocholine cytidylyltransferase-α (LCTα-/-), the regulatory enzyme in the CDP-choline pathway for PC biosynthesis, were fed a...
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Interactions between Amyloid Precursor Protein and Prion Protein Impact Cell Adhesion and Apoptosis in the Developing Zebrafish
DownloadFall 2011
We report here that knockdown of either amyloid precursor protein (APP) or prion protein (PrP) in the zebrafish produces an overt dose-dependent phenotype characterized by systemic morphological defects and CNS cell death. We report findings that the zebrafish PrP-1 gene genetically interacts...
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Spring 2011
In this thesis, measurement and analysis of colloidal forces between an atomic force microscope (AFM) probe and a topographically patterned substrate are reported. The energy between the patterned substrate and a smooth flat plate was characterized mathematically using Surface Element Integration...
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Poxviral manipulation of Bcl-2 proteins: fowlpox virus FPV039 and deerpox virus DPV022 inhibit apoptosis by neutralising Bak and Bax, while Noxa contributes to vaccinia virus-induced apoptosis
DownloadSpring 2011
Poxviruses are renowned for encoding proteins that modulate virtually every aspect of the host immune system. One effective barrier against virus infection is apoptosis, a form of programmed cell death. Apoptosis is controlled at the mitochondria by pro- and anti-apoptotic members of the highly...