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- 2Gänzle, Michael G.
- 2Sawyer, Michael B.
- 1Baracos, Vickie
- 1Baracos, Vickie E.
- 1Bibova, Ilona
- 1Dieleman, Levinus
Intestinal microbiota mediate toxicity of irinotecan (CPT-11) cancer therapies and cause systemic infection after CPT-11-induced loss of barrier function. The intestinal microbiota and their functions are thus potential targets for treatment to mitigate CPT-11 toxicity. However, microbiota...
The role of intestinal microbiota in development of irinotecan toxicity and in toxicity reduction through dietary fibres in ratsDownload
CPT-11 is a drug used as chemotherapy for colorectal cancer. CPT-11 causes toxic side-effects in patients. CPT-11 toxicity has been attributed to the activity of intestinal microbiota, however, intestinal microbiota may also have protective effects in CP!-11 chemotherapy. This study aimed to...