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- 1Boone, Laurie Ann.
- 1Elezzabi, Muhammad A.
- 1Harding, John C. S.
- 1Hong, Linjun
- 1Hou, Shangmei
- 1James, Kevin
- 2Department of Surgery
- 1Department of Agricultural, Food and Nutritional Sciences
- 1Department of Biological Sciences
- 1Department of Cell Biology
- 1Department of Human Ecology
- 1Department of Immunology
Differential responses in placenta and fetal thymus at 12 days post infection elucidate mechanisms of viral level and fetal compromise following PRRSV2 infectionDownload
Background:A pregnant gilt infected with porcine reproductive and respiratory syndrome virus (PRRSV) can transmit the virus to her fetuses across the maternal-fetal-interface resulting in varying disease outcomes. However,the mechanisms leading to variation in fetal outcome in response to PRRSV...
Flaviviruses are important human pathogens that have an enormous impact on global health. Examples that have been studied in my research include dengue virus (DENV), West Nile virus (WNV) and most recently, Zika virus (ZIKV). Currently, there are very few vaccines against or therapeutic...
Characterizing the effects of differentially adapted influenza PB2 proteins on duck MAVS-mediated interferon beta signalingDownload
The influenza A viral RNA polymerase is responsible for viral replication and greatly affects influenza A virus (IAV) virulence and host range. The PB2 influenza polymerase subunit is the primary polymerase determinant of influenza host range and virulence. It was previously shown that PB2...
Chronic Fatigue Mechanisms in Autoimmune Diseases: Lessons from Primary Biliary Cholangitis and Systemic SclerosisDownload
Systemic sclerosis (SSc) is an autoimmune disease affecting the body's connective tissues, resulting in progressive fibrosis and vasculopathy. In some cases, individuals with SSc may also develop primary biliary cholangitis (PBC), another autoimmune disease characterized by damage to their...
Reovirus is a naturally benign virus that preferentially replicates in transformed cells and is currently undergoing clinical trials as a promising oncolytic therapy. In normal mouse fibroblasts, transformation by constitutively activated Ras oncogene is sufficient to promote reovirus infection....
T cell-mediated inflammation is stereotyped: mouse delayed-type hypersensitivity reaction and mouse T cell-mediated rejection of renal allografts share common molecular mechanismsT cell-mediated inflammation is stereotypedDownload
Genome-wide gene expression analysis of diseases has revealed large-scale changes in the expression of thousands of genes (transcripts) representing biological processes. The processes that occur during T cell-mediated rejection (TCMR) of renal allografts in mice and humans have been previously...