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Skip to Search Results- 3Sialic Acid
- 2Glycobiology
- 1Capillary Electrophoresis
- 1Carbohydrate Biosynthesis
- 1Carbohydrate Chemistry
- 1Carbohydrate Glycoprotein
- 3Macauley, Matthew S.
- 2He, Yuan
- 1Arlian, Britni M.
- 1Bennet, Andrew J.
- 1Chan, Jefferson
- 1Davies, Gideon J.
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Metabolism of vertebrate amino sugars with N-glycolyl groups: Intracellular β-O-linked N-glycolylglucosamine (GlcNGc), UDP-GlcNGc,and the biochemical and structural rationale for the substrate tolerance of β-O-linked& beta;-N-acetylglucosaminidase
Download2012
Vocadlo, David J. , Chan, Jefferson, Whitworth, Garrett A., Macauley, Matthew S., Stubbs, Keith A., Varki, Ajit, Davies, Gideon J., Yuzwa, Scott, Zandberg, Wesley, Bennet, Andrew J., He, Yuan
The O-GlcNAc modification involves the attachment of single β-O-linked N-acetylglucosamine residues to serine and threonine residues of nucleocytoplasmic proteins. Interestingly, previous biochemical and structural studies have shown that O-GlcNAcase (OGA), the enzyme that removes O-GlcNAc from...
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2016
O’Dwyer, Michael E., Macauley, Matthew S., Natoni, Alessandro
Aberrant glycosylation is a hallmark of cancer cells with increased evidence pointing to a role in tumor progression. In particular, aberrant sialylation of glycoproteins and glycolipids has been linked to increased immune cell evasion, drug evasion, drug resistance, tumor invasiveness, and...
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Unmasking of CD22 on germinal center B-cells occurs by alternative mechanisms in mouse and man
Download2015
McBride, Ryan, Wang, Shui-Hua , Macauley, Matthew S., Khoo, Kay-Hooi, Paulson, James C., Kannagi, Reiji, Peng, Wenjie, He, Yuan, Kawasaki, Norihito, Arlian, Britni M.
CD22 is an inhibitory B-cell co-receptor whose function is modulated by sialic acid (Sia)-bearing glycan ligands. Glycan remodeling in the germinal center (GC) alters CD22 ligands, with as yet no ascribed biological consequence. Here, we show in both mice and humans that loss of high affinity...