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Skip to Search Results- 60Aging
- 49Older adults
- 27Alzheimer's disease
- 13Long-term care
- 11Cognitive impairment
- 11Continuing care
- 8Forbes, D.
- 7Strain, Laurel A.
- 7Wanless, Deanna
- 6Alberta Centre for Active Living
- 5Forbes, D.A.
- 5Morgan, D.
- 65Graduate and Postdoctoral Studies (GPS), Faculty of
- 65Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
- 28Nursing, Faculty of
- 20Nursing, Faculty of/Chronicity
- 9ACCES Research Group
- 9ACCES Research Group/Research Reports (ACCES)
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Fall 2019
Alzheimer’s disease (AD) is characterized by the accumulation of amyloid beta (Aβ) peptide. It has been proposed that AD pathology is transmissible by a “prion-like” mechanism through extracellular vesicles (EVs) that contain Aβ. In this context, EVs describe both microvesicles and exosomes,...
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2021-02-01
SSHRC IDG awarded 2021. The study examines how stigma of pre-legal cannabis influences older people’s experiences with medical cannabis. Using surveys and interviews, we will examine how stigma perceptions influence older persons' information seeking and access to cannabis for health reasons. ...
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Cardioprotective effects of n-3 and n-6 PUFA derived epoxylipids against age-related cardiac alterations
DownloadSpring 2021
Age-associated changes leading to a decline in cardiac structure and function contribute to the increased susceptibility and incidence of cardiovascular diseases (CVD) in elderly individuals. A steady decline in mitochondrial function is recognized as an important biological consequence found in...
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Cellular level/distribution of γ-secretase subunit nicastrin and its modulator p23 in the brain
DownloadSpring 2010
The processing of amyloid precursor protein (APP) by β- and γ-secretases produces amyloid β (Aβ) peptide, the principal component of the neuritic plaques found in Alzheimer’s disease (AD) pathology. The enzyme γ-secretase is a multimeric protein consisting of presenilins-1/2 (PS1/PS2), nicastrin,...
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Spring 2013
Alzheimer’s disease (AD) is a complex neurodegenerative disorder believed to be triggered by the accumulation of β-amyloid (Aβ)-related peptides derived from the proteolytic processing of amyloid precursor protein (APP). Research over the last two decades has shown that alterations in the levels...
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Fall 2013
Background: Ischemic stroke is associated with cognitive impairment, but the acute cognitive sequelae of transient ischemic attack (TIA) and minor stroke is unknown. We hypothesized that transient cognitive impairment can be predicted by diffusion-weighted imaging (DWI) lesion volume. Methods:...
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Fall 2018
Amyotrophic Lateral Sclerosis (ALS) involves the progressive loss of upper and lower motor neurons. Frontotemporal lobar degeneration (FTLD) has been reported in a considerable proportion of patients, manifesting as cognitive and behavioural impairment in at least 25-50%, with 10-15% patients...