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Skip to Search Results- 1Capsular polysaccharide
- 1Chemical Synthesis
- 1Klebsiella pneumoniae
- 1Lipopolysaccharides
- 1Synthesis, lipopolysaccharide, probe
- 1phosphoramidate
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A Route to Polyprenol Pyrophosphate-Based Probes of O- Polysaccharide Biosynthesis in Klebsiella pneumoniae O2a
Download2019-01-27
Ryan P. Sweeney, Todd L. Lowary
An approach for the assembly of polyprenol pyrophosphate-based probes of O-polysaccharide biosynthesis in Klebsiella pneumoniae serotype O2a is described. This convergent route features high yielding, diastereoselective glycosylations and the late stage installation of the polyprenol...
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Synthesis of Lipopolysaccharide O-antigens from Klebsiella pneumoniae Serotype O2a as Molecular Probes for Biosynthetic Studies
DownloadFall 2018
Many Gram-negative bacteria are pathogenic organisms that can cause disease and death. As antibiotic resistance and nosocomial disease occurrences both increase, these infections are becoming more problematic. These issues can be partially attributed to lipopolysaccharide (LPS), which is a major...
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Synthesis of the Campylobacter jejuni 81-176 strain capsular polysaccharide repeating unit reveals the absolute configuration of its O-methyl phosphoramidate motif
Download2019-01-30
V. Narasimharao Thota, Michael J. Ferguson, Ryan P. Sweeney, Todd L. Lowary
The O-methyl phosphoramidate (MeOPN) motif is a non-stoichiometric modification of capsular polysaccharides (CPS) in ~70% of all Campylobacter jejuni strains. Infections by C. jejuni lead to food-borne illnesses and the CPS they produce are key virulence factors. The MeOPN phosphorus atom in...