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- 2Berry, Tanya R
- 2Veldhoen, Richard
- 1Alberta Centre for Active Living
- 1Alqahtani,Hind M
- 1Bekele, Raie Taye
- 1Benesch, Matthew GK
- 19Graduate Studies and Research, Faculty of
- 19Graduate Studies and Research, Faculty of/Theses and Dissertations
- 3Kinesiology, Sport, and Recreation, Faculty of
- 2Kinesiology, Sport, and Recreation, Faculty of/Research Data and Materials (Physical Education)
- 1St. Stephen's College
- 1St. Stephen's College/Department of Psychotherapy and Spirituality (St. Stephen's College)
Association mapping of genes using whole genome polymorphism arrays: Identification of markers of breast cancer susceptibility in Alberta womenDownload
Breast cancer is a heterogeneous, polygenic disease and is influenced by genetic, environmental and life-style factors. Many single nucleotide polymorphisms (SNPs) associated with breast cancer risk have been identified in genome-wide association studies (GWASs) by several research groups for...
Autotaxin is a secreted enzyme that produces most of the extracellular lysophosphatidate from lysophosphatidylcholine, the most abundant phospholipid in plasma. Lysophosphatidate mediates many physiological and pathological processes by signaling through six G-protein-coupled receptors to promote...
This dissertation explores breast cancer experiences by predominately contemporary American women that are creative interventions into, and re-visions of, experiences in medical and therapeutic environs as well as culturally produced post-surgical bodies. During diagnoses, surgeries and...
DDX17 (P72), a Sox2 binding partner, regulates Sox2 to sustain tumorigenic and stem-like properties in a phenotypically distinct subset of estrogen positive breast cancer cellsDownload
Abstract: Sox2, an embryonic stem cell marker, is involved in the pathogenesis of breast cancer (BC). Sox2 expression is associated with a poor clinical outcome in BC patients. Based on the differential Sox2 transcriptional activity, we have identified the two phenotypically distinct cell...
Tumor targeting ligands provide a promising solution to the problems associated with the selective delivery of conventional cancer chemotherapeutics and diagnostics to cancer cells. Therefore, numerous cancer cell surface targeting peptides have been identified and evaluated. These peptides have...
Establishing the anti-cancer effects of unsaturated fatty acids and a novel oil on human breast cancer cellsDownload
N-3 and n-6 fatty acids and conjugated linoleic (CLA) acid have been known to inhibit breast cancer cell growth, however, effects on normal cells and of single and mixtures of n-3 and n-6 pathway intermediates have not been thoroughly investigated. The objective of this thesis was to determine...
Background: Breast conserving surgery (BCS) followed by radiation is the preferred treatment option for early stage breast cancer because it is less invasive than the alternative treatment, mastectomy, and provides a better cosmetic outcome and a superior quality of life. Positive surgical...
Breast cancer is the most common cancer and the leading cause of cancer-related death among Canadian women. Despite improvements in treatment and early detection, there is still a need to develop novel therapies for breast cancer management. Aberrant Notch signaling is tumorigenic and is...
Breast cancer is the most common cancer among women in the developed world. The disease results from the combined effects of genetic, environmental, reproductive and lifestyle risk factors. Germline DNA variations identified thus far by linkage and genome-wide association studies (GWASs) account...
Evidence-based medicine (EBM) is, simply, the conscientious and judicious use of medical research (“evidence”) in clinical practice (Sackett et al. 2000:1). EBM emerged as a solution to various identified uncertainties in clinical practice as a programme for intervention at the level of...