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- 1Alford, Spencer Caleb
- 1Anbukarasu, Preetam
- 1Arutyunov, Denis
- 1Assempour, Nazanin
- 1Belal, Ahmed S. F.
- 1Carlson, Haley J
An examination of linking and blocking procedures for use in deflection cantilever array-based protein detectionDownload
In this project common linking and blocking procedures were examined for use in multiplexed deflection cantilever array-based detection of proteins. A human interferon gamma (INF-γ) enzyme-linked immunosorbent assay (ELISA) kit was used to evaluate the effectiveness of the linking and blocking...
The detection of biological molecules is a useful tool for diagnostics, research, and general health monitoring. By measuring concentrations of certain key components of biological samples, vital information can be gained as to the condition of the entire biological system. Diseases such as...
The development of rapid detection techniques to be applied at the point of use, has been gaining significant attention in the recent years. Rapid techniques are important and preferable methods in healthcare and environment sector due to the advantages they offer such as low-cost and reduced...
Development of an optical biosensor based on Mach-Zehnder Interferometry for detection of Listeria monocytogenesDownload
Label-free optical biosensors are widely used for the detection of pathogens due to their low-cost, real-time detection and high sensitivity. A Mach-Zehnder Interferometer (MZI) based biosensor has been developed for the detection of gram-positive bacteria, Listeria monocytogenes. An extensive...
The discovery of green fluorescent protein (GFP) from the Aequorea victoria jellyfish revolutionized many fields in the scientific community, including molecular biology, protein engineering, and neuroscience. The ability to genetically link a fluorescent protein to a protein of interest has...
Fluorescent proteins (FPs) are indispensible biochemical tools. The concerted efforts of protein engineers have produced FPs spanning the visible colour spectrum. This wide variety of FPs has greatly facilitated the development of FP-based biosensors. However, researchers rely on relatively few...
The discovery of green fluorescent protein (GFP) from the Aequorea victoria Jellyfish followed by the extensive efforts of protein engineers to produce other fluorescent proteins (FPs) spanning the visible color spectrum made fluorescent proteins indispensable biochemical tools in the scientific...
The discovery and subsequent applications of fluorescent proteins (FPs) launched a new era for live cell fluorescence imaging. The design and developments of FP-based indicators have further solidified the versatility of FPs and rendered them as indispensable tools in life science research now...
Fluorescent proteins (FP) and FP-based biosensors have become essential tools for cell biology and neuroscience research. This thesis describes efforts to engineer new FPs with red emission and novel genetically encoded biosensors based on red FPs. Directed evolution and semi-rational design are...