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  • T Cell Generation in a Lymphopenic Environment Generates Disease when the Thoracic Thymus is Eliminated; Augmentation by IL-7/Anti-IL-7 Complexes
  • Smolarchuk, Christa
  • English
  • T cell, Tolerance, Lymphopenia, Cervical thymus, Autoimmunity
  • Dec 14, 2011 11:55 AM
  • Thesis
  • English
  • Adobe PDF
  • 9921111 bytes
  • Cervical thymus functionally mimics the thoracic thymus in supporting T cell development and exists in a subset of mice and humans. Importantly, it remains unknown whether the cervical thymus generates an overall repertoire of T cells that are self-tolerant similar to the thoracic thymus. Mice that developed T cells in the absence of the T cell output from the thoracic thymus developed a disease characterized by lethargy, swollen eyes and cachexia. Our data supports that the cervical thymus can function in the absence of the thoracic thymus; however, the T cell repertoire is not fully self-tolerant. Evidence suggests that disease occurs as a result of lymphopenia-driven autoimmunity similar to disease seen after transfer of thymocytes into lymphopenic hosts. Therefore, we used this model to demonstrate that IL-7, an important homeostatic cytokine, can augment disease although the mechanism remains to be elucidated.
  • Master's
  • Master of Science
  • Department of Medical Microbiology and Immunology
  • Immunology
  • Spring 2012
  • Anderson, Colin (Surgery and Medical Microbiology and Immunology)
  • Elliott, John (Medicine)
    Baldwin, Troy (Medical Microbiology and Immunology)
    Agrawal, Babita (Surgery)

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