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  • http://hdl.handle.net/10048/2373
  • T cell-mediated inflammation is stereotyped: mouse delayed-type hypersensitivity reaction and mouse T cell-mediated rejection of renal allografts share common molecular mechanisms
    T cell-mediated inflammation is stereotyped
  • Venner, Jeffery
  • en_US
  • Inflammation
    Hypersensitivity
    Hapten
    Rejection
    Allograft
    Gene-expression
    Interferon
  • Sep 30, 2011 4:42 PM
  • Thesis
  • en_US
  • Adobe PDF
  • 1583726 bytes
  • Genome-wide gene expression analysis of diseases has revealed large-scale changes in the expression of thousands of genes (transcripts) representing biological processes. The processes that occur during T cell-mediated rejection (TCMR) of renal allografts in mice and humans have been previously delineated, and they appear to be independent of cytotoxic mechanisms; thus, TCMR is analogous to delayed-type hypersensitivity (DTH). Since TCMR and DTH involve similar mechanisms, we hypothesized the molecular changes in TCMR are stereotyped; thus, they are qualitatively the same as those in DTH. Using microarrays to compare the transcript expression changes of both diseases in mice, we found they share the same processes: T cell and macrophage infiltration, IFNG-effects, alternative macrophage activation, and a coordinated injury-repair response of the tissue parenchyma. Additional analysis revealed IFNG is vital for stabilizing the injury-repair response in TCMR and DTH. We conclude the molecular changes in TCMR and DTH involve stereotyped, coordinated processes.
  • Master's
  • Master of Science
  • Medicine
  • Fall 2011
  • Halloran, Philip (Medicine)
    Mengel, Michael (Laboratory Medicine and Pathology)
  • Anderson, Colin (Surgery)

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