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  • http://hdl.handle.net/10402/era.24991
  • The Tumor Promoting Role of BAD in Breast Cancer Cells
  • Buckland, Timothy, W
  • English
  • BAD
    breast cancer
    tumor growth
    anti-apoptotic
  • Jan 9, 2012 12:45 PM
  • Thesis
  • English
  • Adobe PDF
  • 1874851 bytes
  • In Canada, approximately 40% of the population will be diagnosed with cancer and 25% will die of this disease. In order to treat cancer more effectively, new prognostic and therapeutic targets need to be discovered. In breast cancer, the BH3 only protein BAD has been shown to correlate with response to treatment. However, the role of BAD in cancer is unclear. Although BAD is well characterized as a pro-apoptotic protein, alternative roles exist that may influence cancer progression. In this study, we determine that BAD over-expression promotes proliferation and tumor growth of MDA-MB-231 breast cancer cells. These roles are regulated by serine phosphorylation, specifically serine 118. Finally, enforced phosphorylation of BAD at serine 118 promotes apoptotic resistance. This study suggests that in order to use BAD as a prognostic or therapeutic target, the phospho-status of BAD must also be examined.
  • Master's
  • Master of Science
  • Department of Biochemistry
  • Spring 2012
  • Goping, Ing Swie (Biochemistry)
  • Godbout, Roseline (Oncology)
    Baksh, Shairaz (Pediatrics)
    Fahlman, Richard (Biochemistry)
    Goping, Ing Swie (Biochemistry)