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  • http://hdl.handle.net/10402/era.25302
  • The role of intracellular calcium stores in the myogenic response of rat middle cerebral arteries
  • Tam, Raymond C
  • English
  • Myogenic response
    Intracellular calcium stores
    Cerebral arteries
  • Jan 29, 2012 6:55 PM
  • Thesis
  • English
  • Adobe PDF
  • 3269111 bytes
  • The myogenic response is the ability of resistance arteries to constrict in response to blood pressure increases. As a key autoregulatory mechanism, this ability limits fluctuations in blood flow even when large blood pressure changes occur. The aim of my research is to examine the role of intracellular calcium stores in the myogenic response of rat middle cerebral arteries. I have addressed this aim by using pharmacological approaches to test two hypotheses: 1. smooth muscle sarcoplasmic reticulum (SR) provides an internal calcium source for myogenic response 2. the endothelium can modulate myogenic tone, and disruption of the endothelial endoplasmic reticulum will disturb myogenic reactivity My data demonstrate that in rat middle cerebral arteries, disruption of the smooth muscle cell SR results in loss of myogenic response. Also, although the endothelium does not actively regulate the myogenic response, disruption of endothelial cell calcium regulation can lead to myogenic tone loss.
  • Master's
  • Master of Science
  • Department of Pharmacology
  • Spring 2012
  • Plane, Frances (Pharmacology)
    Kerr, Paul (Grant MacEwan University)
  • Tse, Amy (Pharmacology)
    Hemmings, Denise (Obstetrics and Gynecology)
    Seubert, John (Faculty of Pharmacy & Pharmaceutical Sciences)