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  • http://hdl.handle.net/10402/era.27437
  • Comorbidity, body composition and the progression of advanced colorectal cancer
  • Lieffers, Jessica
  • English
  • colorectal cancer
    cancer cachexia
    body composition
    computed tomography imaging
    liver metastases
    resting energy expenditure
    comorbidities
    Elixhauser comorbidity index
    Charlson comorbidity index
    survival
    nutrition
    weight loss
    ICD codes
  • Jul 5, 2010 7:50 PM
  • Thesis
  • English
  • Adobe PDF
  • 1496370 bytes
  • The purpose of this work was to further understand nutritional status, especially body weight and composition, during colorectal cancer progression. Population-based studies of colorectal cancer patients were conducted using administrative health data (primary and co-morbid diseases, demographics), and computed tomography (CT) imaging (body composition). In cohort 1, administrative health data was used to study comorbidities and nutritional status in 574 colorectal cancer patients referred for chemotherapy. Multivariate Cox regression revealed several comorbidities, performance status and weight loss ≥ 20% predicted survival. In cohort 2, a serial CT image analysis assessed longitudinal body composition changes during the last 12 months preceding death from colorectal cancer (n=34). Body composition changes were typified by exponential increases in liver metastases with concurrent accelerations of muscle and fat loss. These results have the potential to make a difference in how colorectal cancer patients are treated and researched by dietitians, oncologists, and health services researchers.
  • Master's
  • Master of Science
  • Department of Agricultural, Food, and Nutritional Science
  • Fall 2010
  • Baracos, Vickie (Oncology and Agricultural, Food and Nutritional Science)
  • McCargar, Linda (Agricultural, Food and Nutritional Science)
    Fassbender, Konrad (Oncology)