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  • http://hdl.handle.net/10402/era.25339
  • Role of Glucagon-like Peptide-2 and Elemental Formula in Short Bowel Syndrome – Using Neonatal Piglets as an Animal Model
  • Hua, Zheng
  • English
  • short bowel syndrome
    elemental formula
    glucagon-like peptide-2
    animal model
  • Jan 30, 2012 5:17 PM
  • Thesis
  • English
  • Adobe PDF
  • 2124440 bytes
  • Recovery from short bowel syndrome (SBS) requires intestinal adaptation, dependent on enteral nutrition (EN) and peptides, like glucagon-like peptide-2 (GLP-2). The purpose of this thesis was to investigate endogenous GLP-2 production and compare elemental versus polymeric formula in a neonatal animal model of SBS. Piglets were assigned mid-intestinal resection (JI); distal-intestinal resection (JC); or to a sham group. Postoperatively piglet’s commenced parenteral nutrition (PN), tapering as EN (elemental or polymeric) was increased. JI piglets had shorter PN duration (p<0.01), longer villi (p<0.01), deeper crypts (p<0.01) and higher plasma GLP-2 (p<0.001). Adaptation did not occur in JC piglets, while polymeric formula increased their duration of PN support (p<0.05) and plasma GLP-2 (p<0.05). This thesis shows that endogenous GLP-2 production is increased in association with adaptation in SBS piglets with ileum (JI). Polymeric formula increased endogenous GLP-2 in piglets without ileum, but did not benefit adaptation in neonatal SBS.
  • Master's
  • Master of Science
  • Medical Sciences-Paediatrics
  • Spring 2012
  • Turner, Justine M (Paediatrics)
    Wales, Paul W (Surgery, University of Toronto)
  • Mager, Diana (Agricultural, Life and Environmental Sciences)
    Ball, Ron (Agricultural, Life and Environmental Sciences)