ERA Banner

Simon Grange

RSS Feed

We lead a group of researchers developing practical solutions to human machine interfaces and the use of robotics systems in the process of improving healthcare delivery at all levels.

Simon Grange

Rehabilitation Robotics Sandbox

  • Shoulder surgery
  • Strategic Computer Modelling in Healthcare
  • Orthopaedic Informatics

  • MB ChB PhD FRCS(Tr&Orth)

Subject areas and related deposits

  • Brake Pedal

  • Governance

    • Tissue Engineering Stem Cells – An e-Governance Strategy

      The rules of governance are changing. They are necessarily becoming more stringent as interventions offered to treat conditions carry unpredictable side effects, often associated with novel therapeutic vectors. The clinical relevance of this relates to the obligations of those involved in research, to ensure the best protection for subjects whilst encouraging the development of the field. Existing evidence supports the concept of e-Governance both in operational health research and more broadly in the strategic domain of policy formation. Building on the impact of the UK Comprehensive Research Network and recent EU Directives, it is now possible to focus on the issues of regulation for cell therapies in musculoskeletal science through the development of the Advanced Therapeutic Medicinal Products (ATMP) category of research products. This article reviews the framework that has borne this and the need for more detailed Virtual Research Integration and Collaboration (VRIC) systems to ensure regulatory compliance. Technology research and development plans must develop in close association between tissue engineering and treating clinicians. The scope of this strategy relates to the handling of human tissues the transport and storage of specimens in accordance with current EU directives and the Human Tissue Authority (HTA) regulations.

  • Industrialization

    • Establishing Translational Research Pipelines for Smart Devices

      The development of a translational research path has traditionally been a haphazard approach, filtering technologies so that the ‘best of breed’ may ultimately succeed. The conversion ratio of brilliant ideas to useful devices remains suboptimal, as many ‘fail to progress’. The reality of developing biotechnology transfer and Knowledge Transfer (KT) generally, is that the ability of multidisciplinary teams (MDT) to assimilate and then act upon information is becoming the rate limiting step for the building of complex projects. The model proposed here considers both the biological aspects of Life Sciences (LS) and the establishment of Technology Readiness for its implementation.

      Download attached1
  • International Collaboration

  • Intervention

    • Current Issues and Regulations in Tendon Regeneration and Musculoskeletal Repair with Mesenchymal Stem Cells

      Mesenchymal stem cells are multipotent stromal cells residing within the connective tissue of most organs. Their surface phenotype has been well described. Most commonly, mesenchymal stem cells demonstrate the ability to differentiate into mesenchymal tissues (bone, catailge, fat, etc...), however, under the proper conditions these cells can differentiate into epithelial cells and neuroectoderm derived lineages. Their developmental plasticity also depends on the ability of mesenchymal stem cells to alter the tissue microenvironment by secreting soluble factors, as well as their capacity for differentiation in tissue repair. It is the cell-matrix interaction which defines the tissue characteristics. The molecular and functional heterogeneity of this cell population may confound interpretation of their differentiation potential, but it is this heterogeneity that is believed to provide for their therapeutic efficacy. Stem cell therapies are an attractive therapeutic approach for soft tissues as they offer a vehicle for repair and regeneration at the end of a needle. The early introduction of stem cell treatments into the therapeutic armamentarium involves both commercial and non-commercial multidisciplinary partnerships and has occurred in a climate of regulatory reform, so not all the relevant information resides in the public domain, but early clinical studies have shown promising results. Against this backdrop, novel techniques and early results of a small series of tendon and musculotendinous junction interventions are being published and other ongoing studies are yet to report their results. The issue of ensuring governance of these novel technologies falls upon both the scientific community and the established licensing authorities.

  • Nanotoxicity

    • Nanotechnology & Medical Devices: Risk, Regulation and ‘Meta’ Registration

      Integrating data services across the life science spectrum illustrates the design and development of novel therapies in terms of Translational Research (TR) paths. The aim is to build an ‘open’ registry from multiple centres by allowing for open archiving of key characteristics of materials used in the preparation of implantable devices. The standardisation of risk assessment and the subsequent management of this information, challenges the development of new biomedical devices, especially those incorporating nanotechnology

  • Non-Operative Management

  • Rotator Cuff Tear