Establishing a pregnancy cohort for the study of spontaneous preterm birth

  • Author / Creator
    Gracie, Sara
  • Preterm birth is a global challenge. Research on etiologies and risk factors for spontaneous preterm birth appear to be stagnant and circular. New discoveries are needed as are new study approaches that examine gene-environment interactions as etiologies of preterm birth. Guidelines for studies of discovery using ‘-omics’ technologies for preterm birth research are suggested. A prospective community pregnancy cohort is established to integrate ‘-omics’ technologies and environmental data for the study of spontaneous preterm birth and its multifactorial etiological associations. Representative assessments of the Cohort for the provincial pregnant and parenting populations inform scope of generalizability of study findings, assessments current pregnancy and birth cohorts lack. The study design and representativeness assessment presented, as an example of adherence to the guidelines suggested, will serve as a model for future studies on the etiologies of spontaneous preterm birth.

  • Graduation date
    Spring 2011
  • Type of Item
  • Degree
    Master of Science
  • DOI
  • License
    This thesis is made available by the University of Alberta Libraries with permission of the copyright owner solely for non-commercial purposes. This thesis, or any portion thereof, may not otherwise be copied or reproduced without the written consent of the copyright owner, except to the extent permitted by Canadian copyright law.