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Permanent link (DOI): https://doi.org/10.7939/R3ST7F54G

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Mixed-Mode Retention on a Hypercrosslinked Silica-Based Column Open Access

Descriptions

Other title
Subject/Keyword
hypercrosslinked stationary phase
mixed mode retention
silica based
Type of item
Thesis
Degree grantor
University of Alberta
Author or creator
Nedev, Georgi K
Supervisor and department
Dr. Charles Lucy, Department of Chemistry
Examining committee member and department
Dr. Eric Rivard, Department of Chemistry
Dr. Liang Li, Department of Chemistry
Department
Department of Chemistry
Specialization

Date accepted
2012-09-28T13:48:19Z
Graduation date
2012-09
Degree
Master of Science
Degree level
Master's
Abstract
Column stability in Reversed Phase Liquid Chromatography (RPLC) is crucial for obtaining reproducible separations. Under acidic conditions RPLC columns may exhibit stationary phase loss. To address this problem various concepts for improving column acid resistance have been proposed. Carr and co-workers introduced a class of acid stable silica-based RPLC stationary phases based on extensive bonded phase crosslinking. This technology results in the formation of a surface-confined hypercrosslinked polymeric network. One aspect of the column preparation that was not detailed in the literature and is rather perplexing is the column acid conditioning. This thesis explores the synthesis and chromatographic performance of a toluene-derivatized hypercrosslinked silica-based stationary phase (HC-T). This work focuses on the long-term chemical stability and chromatographic behaviour of HC-T after continuous exposure to acid and temperature extremes. It has been demonstrated that the acid treatment results in the formation of cationic functionalities on the hypercrosslinked bonded phase.
Language
English
DOI
doi:10.7939/R3ST7F54G
Rights
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
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