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Permanent link (DOI): https://doi.org/10.7939/R3G142

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Amino acid and biogenic amine concentrations during experimental autoimmune encephalomyelitis and the disease-modifying effects of phenelzine treatment Open Access

Descriptions

Other title
Subject/Keyword
Neurotransmitters
Multiple Sclerosis
Experimental autoimmune encephalomyelitis
Amino acids
Phenelzine
Biogenic amines
Type of item
Thesis
Degree grantor
University of Alberta
Author or creator
Musgrave, Travis
Supervisor and department
Dr. Bradley Kerr (Anesthesiology and Pain Medicine)
Examining committee member and department
Dr. Karim Fouad (Rehabilitation Medicine)
Dr. Glen Baker (Psychiatry)
Dr. Peter Smith (Pharmacology)
Department
Centre for Neuroscience
Specialization

Date accepted
2011-06-02T19:55:09Z
Graduation date
2011-11
Degree
Master of Science
Degree level
Master's
Abstract
The project described in this thesis began with a broad analysis of the changes to amino acid and biogenic amine concentrations in the central nervous system (CNS) during experimental autoimmune encephalomyelitis (EAE) in mice, an animal model of Multiple Sclerosis (MS). That study identified deficits in specific neurotransmitters during EAE that I targeted pharmacologically using the antidepressant drug phenelzine. Phenelzine administration substantially influenced the concentrations of amino acids and biogenic amines in EAE mice in a manner likely to be therapeutic. In the final experiment, I treated EAE mice chronically with phenelzine; This treatment was associated with significant improvements in motor abilities compared to vehicle treated animals. In an open field, improvements were also observed in behavioural indices of depression, physical sickness and anxiety. The results of this thesis may offer new insights into the pathogenesis of EAE and MS and indicate the disease-modifying potential of phenelzine treatment in MS.
Language
English
DOI
doi:10.7939/R3G142
Rights
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
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