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Permanent link (DOI): https://doi.org/10.7939/R3NQ81

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Characterization of NFkB Inhibition by Poxviral Ankyrin/F-box Proteins Open Access

Descriptions

Other title
Subject/Keyword
ankyrin
NFkappaB
poxvirus
Type of item
Thesis
Degree grantor
University of Alberta
Author or creator
Burles, Kristin A
Supervisor and department
Barry, Michele (MMI)
Examining committee member and department
Smiley, Jim (MMI)
Ingham, Rob (MMI)
Barry, Michele (MMI)
Baksh, Shairaz (Pediatrics)
Department
Department of Medical Microbiology and Immunology
Specialization
Virology
Date accepted
2012-09-26T14:20:46Z
Graduation date
2012-09
Degree
Master of Science
Degree level
Master's
Abstract
One of the most notable features of poxviruses is their ability to regulate cellular signaling pathways, including the ubiquitin-proteasome system. Ubiquitin plays a crucial role in the fate of a protein. Typically poly-ubiquitinated proteins are degraded by the 26S proteasome. The Skp1, culllin-1, F-box (SCF) ubiquitin ligase links ubiquitin to a substrate through a family of proteins possessing F-box domains. Recently, our lab has determined that ectromelia virus, the causative agent of lethal mousepox, encodes four F-box-containing proteins, ECTV002, ECTV005, ECTV154, and ECTV165, that interact with the SCF ubiquitin ligase. Many cellular pathways are tightly controlled by the SCF ubiquitin ligase, including the nuclear factor kappa B (NFκB) pathway, which mediates an antiviral immune response. We have shown that the ectromelia ankyrin/F-box proteins inhibit NFκB activation. Our data also suggest that ECTV002 and ECTV154 mediate virion release or spread.
Language
English
DOI
doi:10.7939/R3NQ81
Rights
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
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File format: pdf (Portable Document Format)
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Last modified: 2015:10:12 15:04:57-06:00
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File author: Kristin Burles
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