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Permanent link (DOI): https://doi.org/10.7939/R3FP62

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Characterization of a novel model of intestinal lipoprotein overproduction and the impact of N-3 PUFA supplementation Open Access

Descriptions

Other title
Subject/Keyword
apoB48
cardiovascular disease
n-3 PUFA
lipoprotein
insulin resistance
enterocyte
JCR-LA:cp rat
intestine
chylomicron
Type of item
Thesis
Degree grantor
University of Alberta
Author or creator
Hassanali, Zahra
Supervisor and department
Proctor, Spencer (Agricultural, Food and Nutritional Science)
Examining committee member and department
Vine, Donna (Agricultural, Food and Nutritional Science)
Cheeseman, Chris (Physiology)
Department
Department of Agricultural, Food, and Nutritional Science
Specialization

Date accepted
2009-10-16T14:23:50Z
Graduation date
2009-11
Degree
Master of Science
Degree level
Master's
Abstract
Overproduction of intestinal chylomicrons (CM) has been proposed to contribute to fasting and post-prandial (PP) dyslipidemia and may accelerate the development of cardiovascular disease (CVD) during obesity, insulin resistance (IR) and diabetes. However, the impact of morphological changes in intestinal mucosa structure have not been investigated during IR and intestinal dyslipidemia. The first objective of this thesis was to characterize intestinal villi morphology and to determine whether a morphological relationship exists with enterocytic apoB48 (a marker of CM), and intestinal lymph secretion of apoB48 in the obese and IR JCR:LA-cp rat. The second objective was to assess the impact of n-3 PUFA supplementation on PP dyslipidemia in the JCR:LA-cp rat. Intestinal hypertrophy was observed in IR rats, corresponding to an increase in intestinal and lymphatic apoB48 expression. Further, a dietary intervention of n-3 PUFA showed lower PP plasma concentrations of apoB48 and PP plasma inflammatory markers. We conclude that intestinal hypertrophy may contribute to intestinal CM overproduction during obesity and IR. Additionally, dietary n-3 PUFA improves PP lipemia and the associated PP inflammatory response in the JCR:LA-cp rat model.
Language
English
DOI
doi:10.7939/R3FP62
Rights
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
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Last modified: 2015:10:12 20:10:10-06:00
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File title: Microsoft Word - Hassanali_Zahra_Fall 2009.doc
File author: Zahra Hassanali
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