ERA

Download the full-sized PDF of No stone unturned: rigour versus relevance in systematic reviewsDownload the full-sized PDF

Analytics

Share

Permanent link (DOI): https://doi.org/10.7939/R3B67P

Download

Export to: EndNote  |  Zotero  |  Mendeley

Communities

This file is in the following communities:

Graduate Studies and Research, Faculty of

Collections

This file is in the following collections:

Theses and Dissertations

No stone unturned: rigour versus relevance in systematic reviews Open Access

Descriptions

Other title
Subject/Keyword
methodology
systematic review
cystic fibrosis
antioxidants
Type of item
Thesis
Degree grantor
University of Alberta
Author or creator
Shamseer, Larissa
Supervisor and department
Vohra, Sunita (Pediatrics)
Examining committee member and department
Eurich, Dean (School of Public Health)
Brown, Neil (Pulmonary Medicine)
Johnson, Jeff (School of Public Health)
Vohra, Sunita (Pediatrics)
Department
Public Health Sciences
Specialization

Date accepted
2010-02-05T17:55:59Z
Graduation date
2010-06
Degree
Master of Science
Degree level
Master's
Abstract
INTRODUCTION Antioxidant micronutrients may help alleviate oxidative stress in cystic fibrosis (CF) lung disease. To determine treatment effect, systematic reviews (SR) synthesize available evidence. Cochrane SRs are known for being methodologically rigourous, however, may have limited generalizability. OBJECTIVES To assess effectiveness of antioxidant micronutrients in CF lung disease using Cochrane and non-Cochrane SR methodology; to determine whether Cochrane SRs trade relevance for rigour METHODS The first SR followed Cochrane-preferred methods, while the non-Cochrane SR employed a broader search strategy and nclusion criteria. Reviews were contrasted regarding yield of search, treatment effect (efficacy and safety) and risk of bias. RESULTS Neither SR had enough data to support or refute efficacy or safety of antioxidant supplementation in CF lung disease. Compared to the Cochrane SR, the non-Cochrane SR had four more included studies, more precise estimates of efficacy, additional harms data and a similar risk of bias. CONCLUSION Broader search strategies and inclusion criteria may improve relevance of Cochrane SRs without compromising rigour.
Language
English
DOI
doi:10.7939/R3B67P
Rights
License granted by Larissa Shamseer (shamseer@ualberta.ca) on 2010-02-03T18:12:10Z (GMT): Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of the above terms. The author reserves all other publication and other rights in association with the copyright in the thesis, and except as herein provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
Citation for previous publication

File Details

Date Uploaded
Date Modified
2014-04-29T15:18:41.235+00:00
Audit Status
Audits have not yet been run on this file.
Characterization
File format: pdf (Portable Document Format)
Mime type: application/pdf
File size: 801513
Last modified: 2015:10:12 10:33:38-06:00
Filename: Shamseer_Larissa_Spring 2010.pdf
Original checksum: 5991f2b866d04c67b6652b5e0955c5d1
Well formed: true
Valid: true
File title: Microsoft Word - Shamseer MSc thesis 2010Feb01.doc
File author: lshamseer
Page count: 131
Activity of users you follow
User Activity Date