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Permanent link (DOI): https://doi.org/10.7939/R35Q45

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Enhancing chondrogenesis of mesenchymal stromal cells through anti-Thy1 strategies Open Access

Descriptions

Other title
Subject/Keyword
chondrogenesis
CD90
Thy-1
mesenchymal stem cells
Type of item
Thesis
Degree grantor
University of Alberta
Author or creator
Yu, Hana
Supervisor and department
Adesida, Adetola (Surgery, Biomedical Engineering)
Jomha, Nadr (Surgery)
Examining committee member and department
Jomha, Nadr (Surgery)
Adesida, Adetola (Surgery, Biomedical Engineering)
Churchill, Thomas (Surgery)
Berry, Fred (Surgery, Medical Genetics)
Department
Department of Surgery
Specialization
Experimental Surgery
Date accepted
2014-01-03T10:41:13Z
Graduation date
2014-06
Degree
Master of Science
Degree level
Master's
Abstract
The intricate arrangement and composition of articular cartilage confer the structure its unique material and mechanical properties. Degeneration of articular cartilage, especially osteoarthritis, imposes great burden not only on the patients, but also on society. While there exist various non-surgical and surgical treatment methods, continuous research is required to overcome the limitations of current therapeutic methods. Mesenchymal stromal cell (MSC)-based therapy of cartilage defects has been developed to generate replacement articular chondrocytes for the production of extra cellular matrix. To develop a novel way of advancing MSC-based therapy, we examined the chondrogenic potential of MSCs that have undergone anti-Thy1 treatments. Although several studies have suggested a potential link between Thy-1 and chondrogenic potential of MSCs, our anti-Thy1 strategy did not enhance chondrogenic potential of MSCs. Furthermore, we report that a common lentiviral transduction strategy can compromise MSCs’ chondrogenic capacity, and that Thy-1 expression during chondrogenesis is dynamic in its nature.
Language
English
DOI
doi:10.7939/R35Q45
Rights
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
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