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Permanent link (DOI): https://doi.org/10.7939/R31C1TQ2N

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Voltage gated potassium currents in the Mauthner and MiD2cm cells of larval zebrafish Open Access

Descriptions

Other title
Subject/Keyword
Mauthner
Potassium
Zebrafish
Type of item
Thesis
Degree grantor
University of Alberta
Author or creator
Brewster, Daniel L
Supervisor and department
Ali, Declan (Biological Sciences)
Examining committee member and department
Goss, Greg (Biological Sciences)
Gallin, Warren (Biological Sciences)
Dickson, Clayton (Psychology)
Department
Department of Biological Sciences
Specialization
Physiology, Cell and Developmental Biology
Date accepted
2012-01-31T15:38:17Z
Graduation date
2012-06
Degree
Master of Science
Degree level
Master's
Abstract
The escape response in zebrafish is mediated in part by the Mauthner cell and its two homologues, MiD2cm and MiD3cm. In adult fish, the Mauthner cell fires a single action potential when activated while the homologues fire multiple action potentials. Their distinct firing properties are partially attributed to the differential expression of voltage gated potassium (Kv) channels. I am interested in determining the Kv channels associated with the Mauthner and MiD2cm cells, and if they contain Kv1.1. Immunohistochemistry and in situ hybridization confirmed the expression of Kv1.1 in the Mauthner and MiD2cm cells at 48 hours post fertilization. Electrophysiology showed these cells to contain A-type and delayed rectifier currents but with different current densities. Preliminary data has shown these cells have the same firing behavior as in adults but with distinct action potential waveforms. The presence of Kv1.1 and the distinct current properties are suspected of regulating the neuronal excitability.
Language
English
DOI
doi:10.7939/R31C1TQ2N
Rights
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
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File title: Daniel_Brewster_Spring 2012
File author: Declan Ali
Page count: 182
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