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Gene-Environmental Interaction Assessment in Genome Wide Association Study Open Access


Other title
Heart failure in children--Genetic aspects--Case studies
Anthracyclines--Synthesis--Genetic aspects
Cancer--Genetic aspects--Case studies
Cancer in children--Genetic aspects--Case studies
Congestive heart failure--Genetic aspects--Case studies
Cancer--Environmental aspects
Type of item
Degree grantor
University of Alberta
Author or creator
Liu, Wei
Supervisor and department
Yasui, Yutaka (School of Public Health )
Examining committee member and department
Dr. Yutaka Yasui, School of Public health, University of Alberta
Dr. Smita Bhatia, Department of Population Health Science, City of Hope, California, USA
Dr. Irina Dinu, School of Public health, University of Alberta
Dr. Yan Yuan, School of Public health, University of Alberta
School of Public Health Sciences

Date accepted
Graduation date
Master of Science
Degree level
This thesis aimed to investigate congestive heart failure (CHF) associated with anthracycline exposures among the childhood cancer survivors, trying to identify differential anthracycline effects by genotype of certain genes. We had 130 childhood cancer survivors who developed CHF as cases and 269 individually-matched controls. We assessed each single nucleotide polymorphism’s (SNP) interaction with anthracycline dose on the case-control status of CHF. Besides the single SNP analysis, we developed a method that considered SNPs from the same gene as a set and assessed the set’s effect on anthracycline toxicity by extending a gene-set analysis method developed previously for gene expression studies. Some SNPs had interactions with anthracycline exposure on the development of CHF. Moreover, there was stronger evidence from the SNP-set analysis indicated that the interaction between certain sets of SNPs (genes) and anthracycline exist.
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
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