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Permanent link (DOI): https://doi.org/10.7939/R3FF3M760

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NOREPINEPHRINE-MEDIATED SYNAPTIC PLASTICITY: A NOVEL SIGNALING DIALOGUE BETWEEN RECEPTORS AND NUCLEUS Open Access

Descriptions

Other title
Subject/Keyword
Hippocampus
Epigenetic modifications
Long-term potentiation
Norepinephrine
Type of item
Thesis
Degree grantor
University of Alberta
Author or creator
Maity, Sabyasachi
Supervisor and department
Dr. Peter Nguyen ( Physiology)
Examining committee member and department
Dr. Declan Ali (Biological Sciences)
Dr. Clayton Dickson (Psychology)
Department
Department of Physiology
Specialization

Date accepted
2013-12-10T15:01:51Z
Graduation date
2014-06
Degree
Doctor of Philosophy
Degree level
Doctoral
Abstract
Norepinephrine (NE) helps in the consolidation and retention of memories of emotionally charged events. However, the pathway from membrane receptors to nucleus in noradrenergic signaling in the brain is not completely understood. The cyclic AMP-PKA pathway is one of the most studied signaling pathways recruited by norepinephrine to induce and maintain LTP, a cellular correlate of long term memory. In the present study, I describe a novel signaling mechanism of NE-mediated induction and expression of LTP when paired with a specific stimulus protocol, through cAMP receptors (Epac) instead of PKA. I demonstrate that this pathway involves transcriptional and epigenetic mechanisms other than local protein synthesis. Hence, this unique pathway may be recruited upon novel experience to form a stable memory. Considering that many memory-related cognitive impairments are due to altered pathophysiology of the noradrenergic system, these results both increase our understanding and move us closer to a possible solution for neurological diseases involving neuromodulators like NE.
Language
English
DOI
doi:10.7939/R3FF3M760
Rights
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
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