ERA

Download the full-sized PDF of Study of Enhanced Deposition due to Magnetic Field Alignment of Ellipsoid Particles Using Direct Numerical SimulationsDownload the full-sized PDF

Analytics

Share

Permanent link (DOI): https://doi.org/10.7939/R3KT59

Download

Export to: EndNote  |  Zotero  |  Mendeley

Communities

This file is in the following communities:

Graduate Studies and Research, Faculty of

Collections

This file is in the following collections:

Theses and Dissertations

Study of Enhanced Deposition due to Magnetic Field Alignment of Ellipsoid Particles Using Direct Numerical Simulations Open Access

Descriptions

Other title
Subject/Keyword
Aerosols
Numerical Method
Deposition
Targeting
Type of item
Thesis
Degree grantor
University of Alberta
Author or creator
Martinez, Roberto Carlos
Supervisor and department
Dr. Warren Finlay, Mechanical Engineering
Examining committee member and department
Dr. Carlos Lange, Mechanical Engineering
Dr. Warren Finlay, Mechanical Engineering
Dr. Peter Minev, Mathematical and Statistical Sciences
Department
Department of Mechanical Engineering
Specialization

Date accepted
2012-09-24T10:07:42Z
Graduation date
2012-09
Degree
Master of Science
Degree level
Master's
Abstract
A recent in vitro study demonstrated a non invasive method to enhance local deposition in a small airway by controlling the angular position of magnetic high aspect ratio particles. This technique could mitigate the challenge of providing sufficient therapeutic effects when using aerosolized chemotherapy techniques. To highlight the potential of this new magnetic field alignment approach the effect of increasing particle aspect ratio on the deposition efficiency was studied using direct numerical simulations. Simulations were done using an in house finite element algorithm. A steady air flow, typical of tidal breathing, was simulated through a three dimensional physiologically realistic bifurcation representing a single symmetrical bifurcation between generations 14 and 15 in the lung. For two different aspect ratios the deposition efficiency was found for the case of an unconstrained particle and magnetically aligned particle. Results indicate that forcing local alignment of high aspect ratio particles can increase local deposition considerably.
Language
English
DOI
doi:10.7939/R3KT59
Rights
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
Citation for previous publication

File Details

Date Uploaded
Date Modified
2014-04-28T22:48:35.929+00:00
Audit Status
Audits have not yet been run on this file.
Characterization
File format: pdf (Portable Document Format)
Mime type: application/pdf
File size: 1317945
Last modified: 2015:10:12 16:47:31-06:00
Filename: Martinez_Roberto_Fall 2012.pdf
Original checksum: a1431e37144891f197f4355a56d515c9
Well formed: false
Valid: false
Status message: Lexical error offset=1306170
Page count: 99
Activity of users you follow
User Activity Date