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Permanent link (DOI): https://doi.org/10.7939/R3436D

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Simulation of the Molecular Interactions for the Microcantilever Sensors Open Access

Descriptions

Other title
Subject/Keyword
Nanocantilever
Biosensor
Atomic Force Microscopy
Lattice Spring
Lennard-Jones Potential
Bond Bending Potential
Chemical Detection
Microcantilever Sensor
Molecular Dynamics Simulation
Molecular Interactions
Type of item
Thesis
Degree grantor
University of Alberta
Author or creator
Khosathit, Padet
Supervisor and department
Jar, P.-Y. Ben (Mechanical Engineering)
Choi, Phillip Y. K. (Chemical and Materials Engineering)
Examining committee member and department
Jar, P.-Y. Ben (Mechanical Engineering)
Choi, Phillip Y. K. (Chemical and Materials Engineering)
McDonald, Andre G.
Department
Department of Mechanical Engineering
Specialization

Date accepted
2009-09-30T17:38:44Z
Graduation date
2009-11
Degree
Master of Science
Degree level
Master's
Abstract
Microcantilever sensor has gained much popularity because of its high sensitivity and selectivity. It consists of a micro-sized cantilever that is usually coated on one side with chemical/biological probe agents to generate strong attraction to target molecules. The interactions between the probe and target molecules induce surface stress that bends the microcantilever. This current work applied the molecular dynamics simulation to study the microcantilever system. Lennard-Jones potentials were used to model the target-target and target-probe interactions and bond bending potentials to model the solid cantilever beam. In addition, this work studied the effect of probe locations on the microcantilever deflection. The simulation results suggest that both target-target and target-probe interactions as well as the probe locations affect the arrangement of the bonds; in term of the bonding number, the area containing the bonded molecules, and the distances between them. All these factors influence the microcantilever deflection.
Language
English
DOI
doi:10.7939/R3436D
Rights
License granted by Padet Khosathit (padet@ualberta.ca) on 2009-09-22T18:03:33Z (GMT): Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of the above terms. The author reserves all other publication and other rights in association with the copyright in the thesis, and except as herein provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
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