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Permanent link (DOI): https://doi.org/10.7939/R3PQ7Z

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Comparative investigation on clinical trial designs Open Access

Descriptions

Other title
Subject/Keyword
clinical trial designs, crossover design, N-of-1 trials, response-adaptive designs
Type of item
Thesis
Degree grantor
University of Alberta
Author or creator
Wang, Jing
Supervisor and department
Dr. Keumhee Carriere Chough
Examining committee member and department
Dr. Sunita Vohra
Dr. Pengfei Li
Department
Department of Mathematical and Statistical Sciences
Specialization

Date accepted
2011-10-20T18:48:13Z
Graduation date
2012-06
Degree
Master of Science
Degree level
Master's
Abstract
A number of interesting subjects relevant to optimality of design, cost efficiency evaluation, and the adaptive treatment allocation for response-adaptive repeated measurement designs have been reviewed and discussed. First we introduce some optimal crossover designs, and compare those designs with completely randomized trials and N-of-1 trials in terms of their relative design efficiency and cost saving, followed by a discussion of three statistical models for repeated measurement designs. Then the response-adaptive design in comparison with standard randomized clinical trials has been elaborated. An adaptive treatment allocation scheme for a multiple-objective response-adaptive repeated measurement design is presented in detail; and the simulation study illustrates how the adaptive treatment allocation scheme works efficiently to simultaneously achieve two objectives: increasing estimation precision and treatment benefit.
Language
English
DOI
doi:10.7939/R3PQ7Z
Rights
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
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