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Permanent link (DOI): https://doi.org/10.7939/R31955

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Epithelial cells: an immune modulator in the context of inflammatory bowel diseases Open Access

Descriptions

Other title
Subject/Keyword
Intestinal epithelial cells,TLR9, Innate immunity, Crohn's disease, Ulcerative Colitis
Type of item
Thesis
Degree grantor
University of Alberta
Author or creator
Backer, Jody Lynn
Supervisor and department
Karen Madsen (Medicine)
Examining committee member and department
Catherine Feild (Agricultural, Food and Nutritional Science)
Michael Gänzle ( Agricultural, Food and Nutritional Science)
Richard Fedorak (Medicine)
Department
Medicine
Specialization

Date accepted
2009-09-03T17:31:50Z
Graduation date
2009-11
Degree
MSc.
Degree level
Master's
Abstract
Inflammatory Bowel Diseases (IBD) result from the nexus of a genetic predisposition, dysregulated immunologic insult against commensal microflora, and an environmental trigger. The intestinal epithelium is a single cell layer that separates a highly active mucosal immune system from a large antigenic load in the intestinal lumen. Innate immune recognition combined with a highly regulated adaptive immune response maintains this tolerance. The intestinal epithelium in collusion with antigen presenting cells primarily modulates this activity. In this thesis, we show that, in response to DNA isolated from bacteria, innate toll like receptor 9 (TLR9) activation in intestinal epithelial cells modulates both arms of the immune system, to regulate intestinal homeostasis, and through this mechanism, Bifidobacteria breve DNA exerts its anti-inflammatory function.
Language
English
DOI
doi:10.7939/R31955
Rights
License granted by Jody Backer (backer@ualberta.ca) on 2009-09-01T22:25:36Z (GMT): Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of the above terms. The author reserves all other publication and other rights in association with the copyright in the thesis, and except as herein provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
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File author: University of Alberta
File author: University of Alberta
Page count: 179
File language: en-US
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