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Permanent link (DOI): https://doi.org/10.7939/R3KX4Z

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Inhaled Aerosols Targeted via Magnetic Alignment of High Aspect Ratio Particles: An In Vivo and Optimization Study Open Access

Descriptions

Other title
Subject/Keyword
Targeted Drug Delivery
Pharmaceutical Aerosols
High Aspect Ratio Particles
Type of item
Thesis
Degree grantor
University of Alberta
Author or creator
Redman, Gillian
Supervisor and department
Finlay, Warren (Mechanical Engineering)
Examining committee member and department
Thompson, Richard (Biomedical Engineering)
Vehring, Reinhard (Mechanical Engineering)
Department
Department of Mechanical Engineering
Specialization

Date accepted
2011-01-12T17:34:16Z
Graduation date
2011-06
Degree
Masters of Science
Degree level
Master's
Abstract
An in vivo study with 19 rabbits was completed. Half of the exposed rabbits had a magnetic field placed externally over their right lung. Magnetic resonance images of the lungs were acquired to determine the iron concentrations in the right and left lung of each animal. The right/left ratio increased in the middle and basal regions of the lung. With further optimization, this technique could be an effective method for targeted drug delivery. Additionally, the feasibility of increasing the length of high aspect ratio particles for improved targeted drug delivery was explored. An ultrasonic nozzle was pulsed into a large evaporation chamber. Individual particles were found to be double the original length. However, due to locally increased humidity the droplets were not dried, except with the use of an orifice to rapidly accelerate and break apart the larger droplets. The complications associated with this method make it an undesirable and unfeasible method of creating longer particles.
Language
English
DOI
doi:10.7939/R3KX4Z
Rights
License granted by Gillian Redman (jill.redman@gmail.com) on 2011-01-12T01:59:11Z (GMT): Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of the above terms. The author reserves all other publication and other rights in association with the copyright in the thesis, and except as herein provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
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File title: A working title: the great bunny slaughter of 2009
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