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Permanent link (DOI): https://doi.org/10.7939/R33X50

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Characterization of a novel soluble CSF-1 receptor in teleost fish Open Access

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Other title
Subject/Keyword
immunity
sCSF-1R
macrophage
teleost fish
Type of item
Thesis
Degree grantor
University of Alberta
Author or creator
Lund, Johanna M
Supervisor and department
Barreda, Daniel (Biological Sciences)
Allison, Ted (Biological Sciences)
Examining committee member and department
Fitzsimmons, Carolyn (Agriculture Forestry)
Waskiewicz, Andrew (Biological Sciences)
Department
Department of Biological Sciences
Specialization
Physiology, cell and developmental biology
Date accepted
2012-08-10T14:38:34Z
Graduation date
2012-11
Degree
Master of Science
Degree level
Master's
Abstract
Teleosts rely on innate immunity to protect themselves from pathogens. Colony stimulating factor-1 (CSF-1) and its cognate receptor CSF-1R control survival, proliferation, differentiation and function of macrophages. Recently, a novel soluble form of CSF-1R (sCSF-1R) was identified in goldfish. My studies on characterization of sCSF-1R in goldfish and zebrafish assessed the contributions to development and inflammation. In goldfish and zebrafish, sCSF-1R and CSF-1R are not confined to the hematopoietic compartment and show broad expression. The differential expression of these transcripts showcases heterogeneity in immune responses between outbred individuals. Zebrafish sCSF-1R is expressed early in development, suggesting a role during organism and macrophage development. Finally, CSF-1R and sCSF-1R appear to contribute to inflammation, showing expression changes as peritonitis progresses and resolves. My results should contribute to an increased understanding of the regulation of macrophage development and function in teleosts, and allow for characterization of analogous systems in other vertebrate species.
Language
English
DOI
doi:10.7939/R33X50
Rights
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
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