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The influence of iron therapy on the clinical outcomes, the colonic bacteria microbiome and the urinary metabolomics in iron deficient subjects Open Access


Other title
clinical outcomes
iron deficiency
urinary metabolomics
colonic bacteria microbiome
inflammatory bowel disease
Type of item
Degree grantor
University of Alberta
Author or creator
Lee, Thomas Wei Te
Supervisor and department
Fedorak, Richard (Medicine)
Examining committee member and department
Fedorak, Richard (Medicine)
Ritchie, Bruce (Medicine)
Wine, Eytan (Paediatrics)
van Zanten, Sander (Medicine)

Date accepted
Graduation date
Master of Science
Degree level
Iron deficiency is a common problem facing subjects with inflammatory bowel disease and it is of recurrent nature. It is associated with lethargy, fatigue and poorer cognition independent of anaemia. These symptoms could be reversed with iron supplementation either via oral or intravenous route. However, these two routes may have differential effects on the clinical outcomes such as quality of life and disease activity, the colonic bacterial microbiome composition and the urinary metabolomics. This thesis demonstrated that intravenous iron replacement was superior to oral iron replacement in improving the serum ferritin level and quality of life score. Moreover, compared to intravenous iron therapy, significant colonic bacterial dysbiosis was observed with oral iron therapy. The different urinary metabolite profiles between the two routes of iron therapy indicate the route of iron therapy had differential impact on the host’s and gut microbial metabolisms.
License granted by Thomas Lee ( on 2011-07-22T23:07:44Z (GMT): Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of the above terms. The author reserves all other publication and other rights in association with the copyright in the thesis, and except as herein provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
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