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FACTOR ANALYSIS WITH PRIOR INFORMATION - APPLICATION TO DYNAMIC PET IMAGING Open Access

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Other title
Subject/Keyword
Dynamic PET Imaging
Factor Analysis
Type of item
Thesis
Degree grantor
University of Alberta
Author or creator
Lee, Dong-Chang
Supervisor and department
Riauka, Terence (Oncology)
Examining committee member and department
Jans, Hans (Oncology)
Wilman, Alan (Biomedical Engineering)
Robinson, Don (Oncology)
Department
Department of Oncology
Specialization
Medical Physics
Date accepted
2012-01-30T09:18:49Z
Graduation date
2012-06
Degree
Master of Science
Degree level
Master's
Abstract
The conventional region-of-interest (ROI) method to evaluate dynamic Positron Emission Tomography (PET) images can be complex, time consuming, inaccurate (e.g. partial volume effect), and operator-dependent. To overcome these problems, an optimization-based factor analysis of dynamic structures (FADS) technique with prior information is proposed and validated using a computer-based simulation. The technique is then applied to eight sets of [11C]-Dihydratetrabenazine (DTBZ) dynamic PET volumes to decompose the datasets into factor volumes (FV's) that represent the striatum and the non-striatum tissues of the brain, and associated factor curves (FC's), describing the uptake and the clearance rates (activity per unit time) of the DTBZ radiopharmaceutical for the two tissue types. The extracted FV's and FC's are used for stratifying the healthy subjects from patients with early Parkinson's disease. In conclusion, the proposed FADS technique has the potential to significantly aid in the review process for evaluating dynamic datasets by clinicians.
Language
English
Rights
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
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