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Permanent link (DOI): https://doi.org/10.7939/R3KW84

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Biological Factors in the Etiology of Pulmonary Sarcoidosis Open Access

Descriptions

Other title
Subject/Keyword
Sarcoidosis--Case studies
Sarcoidosis--Etiology
Diseases--Causes and theories of causation
Environmentally induced diseases--Research--Case studies
Type of item
Thesis
Degree grantor
University of Alberta
Author or creator
Schouten, Janine R.
Supervisor and department
Cherry, Nicola (Community and Occupational Medicine)
Examining committee member and department
Robert Cowie, Medicine and Community Health Sciences, University of Calgary
Nicola Cherry, Community and Occupational Medicine, University of Alberta
Amhikaipakan Senthilselvan, Public Health Sciences, University of Alberta
Jeremy Beach, Community and Occupational Medicine, University of Alberta
Igor Burstyn, Environmental and Occupational Health, Drexel University
Department
School of Public Health Sciences
Specialization

Date accepted
2011-09-29T04:48:19Z
Graduation date
2011-11
Degree
Master of Science
Degree level
Master's
Abstract
Background: Sarcoidosis etiology is unknown. It is thought to be an aberrant immune response to unidentified environmental agents with ‘rural living’ emerging as a risk factor. Objective: To determine if specific environmental factors were associated with the risk of sarcoidosis. Methods: A case-referent study: Administrative data was used to identify adult cases first diagnosed in Alberta between 1999 and 2005, and age/sex matched referents with other respiratory conditions. Exposures were determined using an interviewer-administered telephone questionnaire. Duration was calculated. Results: 684 cases and 1454 referents participated. Cases were less likely to have ever smoked. No environmental factors had a confidence interval excluding 1 for exposure periods: birth, birth–5 years, and birth–diagnosis. Associations with un-piped water were identified when cases were compared with asthma and non-asthma referents, with cases more likely than asthma referents to drink un-piped water. Conclusions: No strong association between environmental factors and sarcoidosis was observed.
Language
English
DOI
doi:10.7939/R3KW84
Rights
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
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