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Permanent link (DOI): https://doi.org/10.7939/R3KW84
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Biological Factors in the Etiology of Pulmonary Sarcoidosis Open Access
- Other title
Diseases--Causes and theories of causation
Environmentally induced diseases--Research--Case studies
- Type of item
- Degree grantor
University of Alberta
- Author or creator
Schouten, Janine R.
- Supervisor and department
Cherry, Nicola (Community and Occupational Medicine)
- Examining committee member and department
Robert Cowie, Medicine and Community Health Sciences, University of Calgary
Nicola Cherry, Community and Occupational Medicine, University of Alberta
Amhikaipakan Senthilselvan, Public Health Sciences, University of Alberta
Jeremy Beach, Community and Occupational Medicine, University of Alberta
Igor Burstyn, Environmental and Occupational Health, Drexel University
School of Public Health Sciences
- Date accepted
- Graduation date
Master of Science
- Degree level
Sarcoidosis etiology is unknown. It is thought to be an aberrant immune response to unidentified environmental agents with ‘rural living’ emerging as a risk factor.
To determine if specific environmental factors were associated with the risk of sarcoidosis.
A case-referent study: Administrative data was used to identify adult cases first diagnosed in Alberta between 1999 and 2005, and age/sex matched referents with other respiratory conditions. Exposures were determined using an interviewer-administered telephone questionnaire. Duration was calculated.
684 cases and 1454 referents participated. Cases were less likely to have ever smoked. No environmental factors had a confidence interval excluding 1 for exposure periods: birth, birth–5 years, and birth–diagnosis. Associations with un-piped water were identified when cases were compared with asthma and non-asthma referents, with cases more likely than asthma referents to drink un-piped water.
No strong association between environmental factors and sarcoidosis was observed.
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