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Permanent link (DOI): https://doi.org/10.7939/R3BG2HH5W

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Decision making under risk in multiple sclerosis Open Access

Descriptions

Other title
Subject/Keyword
multiple sclerosis
cognition
neuropsychology
neuroimaging
decision making
game of dice task
atrophy
executive functions
ventricular width
decision making under risk
linear measurements
Type of item
Thesis
Degree grantor
University of Alberta
Author or creator
Radomski, Ashley D
Supervisor and department
Fujiwara, Esther (Psychiatry)
Examining committee member and department
Dixon, Roger (Psychology)
Purdon, Scot (Psychiatry)
Power, Chris (Neurology)
Department
Department of Psychiatry
Specialization
Epidemiology
Date accepted
2013-09-29T17:25:36Z
Graduation date
2013-11
Degree
Master of Science
Degree level
Master's
Abstract
Cognitive deficits affect approximately 50% of multiple sclerosis (MS) patients and are associated with disease-related neurodegeneration. Prior MS-studies found decision making impairments uncorrelated with patients’ cognitive functions. Brain correlates of decision making in MS have not been established. The Game of Dice Task (GDT) measures decision making under risk and was used here for the first time in MS patients. I tested healthy controls with either cognitive or brain measures (each n=20), 13 mildly-disabled relapsing-remitting (RR) (“RR-1”), 9 RRMS moderately-disabled (“RR-2”), and 10 secondary progressive (“SP”) MS patients. GDT was impaired in RR-2 and SP subgroups. GDT correlated with processing speed in all patients, but also with executive functions in RR-2 patients. Ventricular width measures indicated atrophy in RR-2 and SP. In all patients, atrophy correlated with decision making and processing speed. Decision making under risk is impaired in later-stage MS and is related to cognition and brain atrophy.
Language
English
DOI
doi:10.7939/R3BG2HH5W
Rights
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
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File author: ashleyradomski
Page count: 175
File language: en-US
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