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Permanent link (DOI): https://doi.org/10.7939/R3RD0T

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Development of Empirical Models to Predict Deposition of Aerosols in the Extrathoracic Airways of Children Open Access

Descriptions

Other title
Subject/Keyword
Aerosol
Deposition
Children
Type of item
Thesis
Degree grantor
University of Alberta
Author or creator
Golshahi, Laleh
Supervisor and department
Finlay, Warren (Mechanical Engineering)
Examining committee member and department
Noga, Michelle (Radiology and Diagnostic Imaging)
Lange, Carlos (Mechanical Engineering)
Vehring, Reinhard (Mechanical Engineering)
Olfert, Jason (Mechanical Engineering)
Devadason, Sunalene (School of Pediatrics and Child Health, University of Western Australia)
Department
Department of Mechanical Engineering
Specialization

Date accepted
2012-03-29T12:04:54Z
Graduation date
2012-06
Degree
Doctor of Philosophy
Degree level
Doctoral
Abstract
The experimental studies described in this thesis were performed with the goal of measuring deposition of aerosols, inhaled either nasally or orally, in the extrathoracic airways of children in different age groups. We pursued in vitro methods and characterized the deposition of aerosols in the extrathoracic airway models of children to address the current concerns in the area of pediatric dosimetry. Using rapid prototyping, nasal airways of ten adults and fourteen children 4-14 years old as well as oral airways of nine children 6-14 years old were replicated from CT scans and MRI images during the course of this research. In addition to these 33 plastic replicas, ten previously-built nasal airway replicas of infants were also used to develop three empirical models to predict the deposition of ultrafine aerosols in nasal airways of infants and the deposition of micrometer-sized particles in the nasal and oropharyngeal airways of children. One of the goals of this study was also to develop a simplified idealized child throat model that could simulate the average oropharyngeal deposition among the children 6-14 years old. The resulting idealized child model presented here will hopefully simplify and accelerate the development of new inhalable drugs for the pediatric population suffering from respiratory diseases.
Language
English
DOI
doi:10.7939/R3RD0T
Rights
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
Citation for previous publication
Golshahi, L., Finlay, W. H., Olfert, J. S., Thompson, R. B., and Noga, M. L. (2010). Deposition of Inhaled Ultrafine Aerosols in Replicas of Nasal Airways of Infants. Aerosol Science and Technology, 44,741-752.Golshahi, L., Noga, M. L., Thompson, R. B., and Finlay, W. H. (2011). In vitro deposition measurement of inhaled micrometer-sized particles in extrathoracic airways of children and adolescents during nose breathing. Journal of Aerosol Science, 42(7), 474-488.Finlay, W. H., Golshahi, L., and Noga, M. L. (2012). New validated extrathoracic and pulmonary deposition models for infants and children. Accepted to appear in Respiratory Drug Delivery 2012 (ISBN Volume 3, 1-933722-59-2), Richard N. Dalby, Peter R. Byron, Joanne Peart, Stephen J. Farr, Julie D. Suman and Paul Young, Editors, Davis Healthcare, River Grove, Illinois (May, 2012).

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File author: Laleh Golshahi
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