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Permanent link (DOI): https://doi.org/10.7939/R3DP9W

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Celiac disease in children with inflammatory bowel disease: a prospective cohort study Open Access

Descriptions

Other title
Subject/Keyword
children
inflammatory bowel disease
celiac disease
Type of item
Thesis
Degree grantor
University of Alberta
Author or creator
El-Matary, Wael
Supervisor and department
Spady, Donald (Department of Pediatrics, Faculty of Medicine)
Examining committee member and department
Fedorak, Richard (Department of Gastroenterology, Faculty of Medicine)
Dieleman, Levinus (Department of Gastroenterology, Faculty of Medicine)
Senthilselvan, Ambikaipakan (School of Public Health)
Department
School Public Health Sciences
Specialization
Clinical Epidemiology
Date accepted
2012-03-28T08:50:26Z
Graduation date
2012-06
Degree
Master of Science
Degree level
Master's
Abstract
The aim of this work was to examine any possible IBD activity-related variations in immunoglobulin A (IgA) anti-tissue transglutaminase (tTG) levels in children with IBD. The prevalence of CD in children with IBD was also examined. In a prospective cohort study, children with IBD were screened for celiac disease using anti-tTG IgA antibodies and endoscopy performed if positive. Age-matched controls without IBD were recruited. One hundred and sixty four children were recruited in each arm of the study. There was no correlation between changes in IgA anti-tTG antibody titers and changes in disease activity indices. The prevalence of celiac disease among patients and controls was similar (1/164 (0.6%)). In children with IBD, changes in disease activity do not significantly affect serum levels of anti-tTG IgA antibodies. Anti-tTG IgA antibodies should not be used to monitor IBD activity. Children with IBD should not be routinely screened for CD.
Language
English
DOI
doi:10.7939/R3DP9W
Rights
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
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