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Passive and non-mechanical pumping in microfluidic devices Open Access


Other title
non-mechanical pumping
capillary filling
passive pumping
electroosmotic flow
Type of item
Degree grantor
University of Alberta
Author or creator
Waghmare, Prashant Rakhmaji
Supervisor and department
Mitra, Sushanta (Mechanical Engineering)
Examining committee member and department
Mitra, Sushanta (Mechanical Engineering)
Parameswaran, Meenakshinathan (School of Engineeing Science, Somon Fraser University)
Bhattacharjee, Subir (Mechanical Engineering)
Thundat, Thomos (Chemical and Materials Engineering)
Yeung, Anthony (Chemical and Materials Engineering)
Secanell, Marc (Mecahnical Engineering)
Department of Mechanical Engineering

Date accepted
Graduation date
Doctor of Philosophy
Degree level
Last couple of decades have witnessed massive upsurge in efforts of transporting and manipulating solutes and moieties in microfluidic devices. Classical pressure-driven transport demands massive pumping power for microchannels making it unusable in several microfluidic applications. Accordingly, there have been a plethora of endeavors to devise novel non-mechanical fluid driving techniques in microchannels, e.g., transport by applying electrostatic, magnetic, or acoustic forces. However, these mechanisms often necessitate special fluid properties, and cumbersome fabrication requirements. Hence, there has been a tremendous drive to develop passive pumping mechanisms that successfully exploit the inherent geometric and physical characteristics of the microchannel and the fluid, yet are free from the above constraints. Several aspects of one of the foremost microfluidic passive pumping mechanisms, namely capillary-driven transport, have been presented here. Firstly, the effect of a transient velocity profile on a classical capillary filling problem has been investigated. All the existing analyses invariably consider a fully-developed velocity profile and accordingly, the proposed model could reveal several yet unaddressed non-trivial mechanisms inherent in a capillary filling problem. Secondly, an appropriate analytical model has been developed to describe the pressure-field at the entrance of the capillary. This pressure-field improves on the existing expressions in the sense that it is applicable to capillaries of all possible aspect ratios, and manifests its influence by predicting a capillary filling length that is different from that hypothesized by the existing models. Thirdly, important correlations interrelating the wetting and other physical properties of popular biomicrofluidic solvents such as BSA (Bovine Serum Albumin) solution or microbead suspension have been derived from thoroughly performed experimental studies. These correlations are next employed to study the capillary dynamics of these two liquids as a function of its physical properties. Finally, effects of additional body forces, such as gravity or electrostatics, in affecting a capillary transport have been investigated.
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
Citation for previous publication
Waghmare, P. R. and Mitra S. K. (2010). Analytica Chemica ActaWaghmare, P. R. and Mitra S. K. (2010). Journal of Fluid EngineeringWaghmare, P. R. and Mitra S. K. (2010). LangmuirWaghmare, P. R. and Mitra S. K. (2010). Journal of Colloid and Interface ScienceWaghmare, P. R. and Mitra S. K. (2012). Microfluidics and nanofluidicsWaghmare, P. R. and Mitra S. K. (2012). Colloid and Polymer Science

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