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Permanent link (DOI): https://doi.org/10.7939/R3VH5CQ90

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Epidemiological Characteristics and Ecological Investigation of the 2009 Influenza Pandemic Open Access

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Other title
Subject/Keyword
RSV
Respiratory
hMPV
Epidemiology
Viruses
Pandemic
Influenza A(H1N1)
Ecological
Type of item
Thesis
Degree grantor
University of Alberta
Author or creator
Elamy, Abdel-Halim H
Supervisor and department
Senthilselvan, Ambikaipakan (Public Health Sciences)
Mukhi, Shamir (Public Health Sciences)
Examining committee member and department
Senthilselvan, Ambikaipakan (Public Health Sciences)
Lee, Bonita (Medicine, Pediatrics)
Mukhi, Shamir (Public Health Sciences)
Plitt, Sabrina (Public Health Sciences)
Department
Department of Public Health Sciences
Specialization
Epidemiology
Date accepted
2014-09-12T10:12:42Z
Graduation date
2014-11
Degree
Master of Science
Degree level
Master's
Abstract
Influenza pandemic occurs when a novel influenza virus subtype for which humans do not have sufficient immunity emerges and spreads quickly from person-to-person worldwide. Influenza pandemics result in serious consequences on human health and economy. In April 2009, the World Health Organization (WHO) announced the emergence of a novel swine-origin influenza virus, A(H1N1)pdm09. This was the first influenza pandemic since 1968. The virus embraced a novel combination of gene segments that had not been reported in the past. By April 2010, 428 related deaths were reported in Canada, including 72 from Alberta. The objective of thesis was to investigate the epidemiologic characteristics of influenza A(H1N1)pdm09 using the data from the Provincial Laboratory for Public Health (ProvLab) and linking it with relevant databases from other sources including those from Statistics Canada and Alberta Health. In Alberta, influenza A(H1N1)pdm09 resulted in 6,327 laboratory-confirmed cases. Of these, 48% were males and 83.6% occurred in summer. The highest and lowest rates were reported in the Central and South Zones of Alberta, respectively. Females were at 12% increased risk compared to males. Individuals with asthma were at 6% increased risk of A(H1N1)pdm09 than others without asthma. Individuals aged between 15 and 34 years had 4-fold increased risk compared to those aged 65 years and older. A switch in the vulnerability to A(H1N1)pdm09 occurred in females between 15 to 64 years of age to have higher risk than males. Associations between influenza A(H1N1)pdm09 virus and other factors (geography, age, sex, and asthma) were found significant in an ecological analysis which is consistent with findings from other studies. Consideration of these factors can result in a more effective public health preparedness and responses to future influenza pandemics.
Language
English
DOI
doi:10.7939/R3VH5CQ90
Rights
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
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